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dc.contributor.authorFankhauser, Christian D
dc.contributor.authorNuño, Michelle M
dc.contributor.authorMurray, Matthew
dc.contributor.authorFrazier, Lindsay
dc.contributor.authorBagrodia, Aditya
dc.date.accessioned2022-04-27T23:30:27Z
dc.date.available2022-04-27T23:30:27Z
dc.date.issued2022-05-07
dc.identifier.issn2405-4569
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336518
dc.description.abstractTesticular germ cell tumours (GCTs) are the most common malignancy among young men. Management of GCTs relies on the serum tumour markers α-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase, among other parameters. However, these tumour markers can only be detected at elevated levels in half of GCT patients. Circulating miR-371a-3p has emerged as a blood-based biomarker that can reliably detect macroscopic GCTs, aside from teratoma. Here we review the literature, describe the methodologies currently used to measure circulating miR-371a-3p, and discuss the following clinical scenarios in which miR-371a-3p may impact practice in the future: (1) men with an inconclusive small testicular mass; (2) response monitoring during chemotherapy; (3) postchemotherapy residual masses; and (4) follow-up after treatment with curative intent. PATIENT SUMMARY: We discuss the potential uses and promise, as well as current limitations, of a novel blood test that may improve care for men with testicular cancer.
dc.description.sponsorshipNone
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleCirculating MicroRNAs for Detection of Germ Cell Tumours: A Narrative Review.
dc.typeArticle
dc.publisher.departmentDepartment of Pathology
dc.date.updated2022-04-25T15:50:26Z
prism.publicationNameEur Urol Focus
dc.identifier.doi10.17863/CAM.83938
dcterms.dateAccepted2022-04-24
rioxxterms.versionofrecord10.1016/j.euf.2022.04.008
rioxxterms.versionAM
dc.contributor.orcidMurray, Matthew [0000-0002-4480-1147]
dc.identifier.eissn2405-4569
rioxxterms.typeJournal Article/Review
cam.orpheus.successWed May 25 11:13:43 BST 2022 - Embargo updated
cam.depositDate2022-04-25
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-05-07


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International