Targeting Microtubules for the Treatment of Heart Disease.
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Publication Date
2022-05-27Journal Title
Circ Res
ISSN
0009-7330
Publisher
Ovid Technologies (Wolters Kluwer Health)
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Warner, E. F., Li, Y., & Li, X. (2022). Targeting Microtubules for the Treatment of Heart Disease.. Circ Res https://doi.org/10.1161/CIRCRESAHA.122.319808
Abstract
Heart disease remains the leading cause of morbidity and mortality worldwide. With the advancement of modern technology, the role(s) of microtubules in the pathogenesis of heart disease has become increasingly apparent, though currently there are limited treatments targeting microtubule-relevant mechanisms. Here, we review the functions of microtubules in the cardiovascular system and their specific adaptive and pathological phenotypes in cardiac disorders. We further explore the use of microtubule-targeting drugs and highlight promising druggable therapeutic targets for the future treatment of heart diseases.
Sponsorship
BHF
Funder references
British Heart Foundation (None)
British Heart Foundation (PG/17/69/33229)
Identifiers
External DOI: https://doi.org/10.1161/CIRCRESAHA.122.319808
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336529
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