Targeting Microtubules for the Treatment of Heart Disease.
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Peer-reviewed
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Abstract
Heart disease remains the leading cause of morbidity and mortality worldwide. With the advancement of modern technology, the role(s) of microtubules in the pathogenesis of heart disease has become increasingly apparent, though currently there are limited treatments targeting microtubule-relevant mechanisms. Here, we review the functions of microtubules in the cardiovascular system and their specific adaptive and pathological phenotypes in cardiac disorders. We further explore the use of microtubule-targeting drugs and highlight promising druggable therapeutic targets for the future treatment of heart diseases.
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Keywords
Colchicine, MAP4, cardiovascular system, heart diseases, microtubules, protein processing, post-translational, tubulin modulators, Heart Diseases, Humans, Microtubules, Tubulin
Journal Title
Circ Res
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Journal ISSN
0009-7330
1524-4571
1524-4571
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Publisher
Ovid Technologies (Wolters Kluwer Health)
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British Heart Foundation (None)
British Heart Foundation (PG/17/69/33229)
British Heart Foundation (PG/17/69/33229)
BHF