Show simple item record

dc.contributor.authorNnaji, Chukwudi A
dc.contributor.authorKuodi, Paul
dc.contributor.authorWalter, Fiona M
dc.contributor.authorMoodley, Jennifer
dc.date.accessioned2022-04-28T08:00:26Z
dc.date.available2022-04-28T08:00:26Z
dc.date.issued2022-04-25
dc.date.submitted2021-06-14
dc.identifier.issn2044-6055
dc.identifier.otherbmjopen-2021-054501
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336543
dc.description.abstractOBJECTIVES: To systematically synthesise available evidence on the nature and effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low and middle-income countries (LMICs). DESIGN: A systematic review of published evidence. The review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses. DATA SOURCES: A comprehensive search of published literature was conducted. In addition, relevant grey literature sources and bibliographical references of included studies were searched for potentially eligible evidence. STUDY SELECTION: Studies published between January 2010 and November 2020 were eligible for inclusion. To be eligible, studies had to report on interventions/strategies targeted at women, the general public or healthcare workers, aimed at improving the timely diagnosis of breast and/or cervical cancers in LMIC settings. DATA EXTRACTION AND SYNTHESIS: Literature search, screening, study selection, data extraction and quality appraisal were conducted by two independent reviewers. Evidence was synthesised and reported using a global taxonomy framework for early cancer diagnosis. RESULTS: From the total of 10 593 records identified, 21 studies conducted across 20 LMICs were included in this review. Most of the included studies (16/21) focused primarily on interventions addressing breast cancers; two focused on cervical cancer while the rest examined multiple cancer types. Reported interventions targeted healthcare workers (12); women and adolescent girls (7) and both women and healthcare workers (3). Eight studies reported on interventions addressing access delays; seven focused on interventions addressing diagnostic delays; two reported on interventions targeted at addressing both access and diagnostic delays, and four studies assessed interventions addressing access, diagnostic and treatment delays. While most interventions were demonstrated to be feasible and effective, many of the reported outcome measures are of limited clinical relevance to diagnostic timeliness. CONCLUSIONS: Though limited, evidence suggests that interventions aimed at addressing barriers to timely diagnosis of breast and cervical cancer are feasible in resource-limited contexts. Future interventions need to address clinically relevant measures to better assess efficacy of interventions. PROSPERO REGISTRATION NUMBER: CRD42020177232.
dc.languageen
dc.publisherBMJ
dc.subjectPublic health
dc.subject1506
dc.subject1724
dc.subjectoncology
dc.subjectbreast tumours
dc.subjectpublic health
dc.subjectorganisation of health services
dc.titleEffectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low-income and middle-income countries: a systematic review.
dc.typeArticle
dc.date.updated2022-04-28T08:00:26Z
prism.issueIdentifier4
prism.publicationNameBMJ Open
prism.volume12
dc.identifier.doi10.17863/CAM.83963
dcterms.dateAccepted2022-03-29
rioxxterms.versionofrecord10.1136/bmjopen-2021-054501
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2022-04-25
dc.contributor.orcidNnaji, Chukwudi A [0000-0002-4132-1922]
dc.contributor.orcidKuodi, Paul [0000-0003-2483-3499]
dc.contributor.orcidWalter, Fiona M [0000-0002-7191-6476]
dc.contributor.orcidMoodley, Jennifer [0000-0002-9398-5202]
dc.identifier.eissn2044-6055
pubs.funder-project-idUniversity of Cape Town (Not applicable)
pubs.funder-project-idGlaxoSmithKline Africa Non-Communicable Disease Open Lab (023)
pubs.funder-project-idNational Department of Health (Not applicable)
pubs.funder-project-idCancer Association of South Africa (CANSA) (Not applicable)
pubs.funder-project-idUK Medical Research Council (Newton Fund). (Not applicable)
cam.issuedOnline2022-04-25
rioxxterms.freetoread.startdate2022-04-25
rioxxterms.freetoread.startdate2022-04-25


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record