Show simple item record

dc.contributor.authorISARIC Clinical Characterisation Group
dc.contributor.authorHall, Matthew D
dc.contributor.authorBaruch, Joaquín
dc.contributor.authorCarson, Gail
dc.contributor.authorCitarella, Barbara Wanjiru
dc.contributor.authorDagens, Andrew
dc.contributor.authorDankwa, Emmanuelle A
dc.contributor.authorDonnelly, Christl A
dc.contributor.authorDunning, Jake
dc.contributor.authorEscher, Martina
dc.contributor.authorKartsonaki, Christiana
dc.contributor.authorMerson, Laura
dc.contributor.authorPritchard, Mark
dc.contributor.authorWei, Jia
dc.contributor.authorHorby, Peter W
dc.contributor.authorRojek, Amanda
dc.contributor.authorOlliaro, Piero L
dc.date.accessioned2022-04-28T23:30:40Z
dc.date.available2022-04-28T23:30:40Z
dc.date.issued2021-11-23
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336588
dc.description.abstractBackground: There is potentially considerable variation in the nature and duration of the care provided to hospitalised patients during an infectious disease epidemic or pandemic. Improvements in care and clinician confidence may shorten the time spent as an inpatient, or the need for admission to an intensive care unit (ICU) or high dependency unit (HDU). On the other hand, limited resources at times of high demand may lead to rationing. Nevertheless, these variables may be used as static proxies for disease severity, as outcome measures for trials, and to inform planning and logistics. Methods: We investigate these time trends in an extremely large international cohort of 142,540 patients hospitalised with COVID-19. Investigated are: time from symptom onset to hospital admission, probability of ICU/HDU admission, time from hospital admission to ICU/HDU admission, hospital case fatality ratio (hCFR) and total length of hospital stay. Results: Time from onset to admission showed a rapid decline during the first months of the pandemic followed by peaks during August/September and December 2020. ICU/HDU admission was more frequent from June to August. The hCFR was lowest from June to August. Raw numbers for overall hospital stay showed little variation, but there is clear decline in time to discharge for ICU/HDU survivors. Conclusions: Our results establish that variables of these kinds have limitations when used as outcome measures in a rapidly evolving situation. Funding: This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mediumElectronic
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectICU
dc.subjectSARS-CoV-2
dc.subjectepidemiology
dc.subjectglobal health
dc.subjecthospitalisation
dc.subjecthuman
dc.subjectmedicine
dc.subjectviruses
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCOVID-19
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHospitalization
dc.subjectHumans
dc.subjectInfant
dc.subjectIntensive Care Units
dc.subjectLength of Stay
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOutcome Assessment, Health Care
dc.subjectRetrospective Studies
dc.subjectSARS-CoV-2
dc.subjectYoung Adult
dc.titleTen months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort.
dc.typeArticle
dc.date.updated2022-04-28T09:58:43Z
prism.publicationDate2021
prism.publicationNameElife
prism.volume10
dc.identifier.doi10.17863/CAM.84010
dcterms.dateAccepted2021-11-18
rioxxterms.versionofrecord10.7554/eLife.70970
rioxxterms.versionVoR
dc.contributor.orcidHall, Matthew D [0000-0002-2671-3864]
dc.contributor.orcidMerson, Laura [0000-0002-4168-1960]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-11-23
cam.depositDate2022-04-28
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International