Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study.
dc.contributor.author | Sullivan, Michael K | |
dc.contributor.author | Lees, Jennifer S | |
dc.contributor.author | Drake, Thomas M | |
dc.contributor.author | Docherty, Annemarie B | |
dc.contributor.author | Oates, Georgia | |
dc.contributor.author | Hardwick, Hayley E | |
dc.contributor.author | Russell, Clark D | |
dc.contributor.author | Merson, Laura | |
dc.contributor.author | Dunning, Jake | |
dc.contributor.author | Nguyen-Van-Tam, Jonathan S | |
dc.contributor.author | Openshaw, Peter | |
dc.contributor.author | Harrison, Ewen M | |
dc.contributor.author | Baillie, J Kenneth | |
dc.contributor.author | ISARIC4C Investigators | |
dc.contributor.author | Semple, Malcolm G | |
dc.contributor.author | Ho, Antonia | |
dc.contributor.author | Mark, Patrick B | |
dc.date.accessioned | 2022-04-28T23:30:49Z | |
dc.date.available | 2022-04-28T23:30:49Z | |
dc.date.issued | 2022-01-25 | |
dc.identifier.issn | 0931-0509 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/336591 | |
dc.description.abstract | BACKGROUND: Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities and non-White race. METHODS: A prospective multicentre cohort study was performed using patients admitted to 254 UK hospitals with COVID-19 between 17 January 2020 and 5 December 2020. RESULTS: Of 85 687 patients, 2198 (2.6%) received acute kidney replacement therapy (KRT). Of 41 294 patients with biochemistry data, 13 000 (31.5%) had biochemical AKI: 8562 stage 1 (65.9%), 2609 stage 2 (20.1%) and 1829 stage 3 (14.1%). The main risk factors for KRT were chronic kidney disease (CKD) [adjusted odds ratio (aOR) 3.41: 95% confidence interval 3.06-3.81], male sex (aOR 2.43: 2.18-2.71) and Black race (aOR 2.17: 1.79-2.63). The main risk factors for biochemical AKI were admission respiratory rate >30 breaths per minute (aOR 1.68: 1.56-1.81), CKD (aOR 1.66: 1.57-1.76) and Black race (aOR 1.44: 1.28-1.61). There was a gradated rise in the risk of 28-day mortality by increasing severity of AKI: stage 1 aOR 1.58 (1.49-1.67), stage 2 aOR 2.41 (2.20-2.64), stage 3 aOR 3.50 (3.14-3.91) and KRT aOR 3.06 (2.75-3.39). AKI rates peaked in April 2020 and the subsequent fall in rates could not be explained by the use of dexamethasone or remdesivir. CONCLUSIONS: AKI is common in adults hospitalized with COVID-19 and it is associated with a heightened risk of mortality. Although the rates of AKI have fallen from the early months of the pandemic, high-risk patients should have their kidney function and fluid status monitored closely. | |
dc.format.medium | ||
dc.publisher | Oxford University Press (OUP) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | COVID-19 | |
dc.subject | SARS-CoV-2 | |
dc.subject | acute kidney injury | |
dc.subject | dialysis | |
dc.subject | renal failure | |
dc.subject | Acute Kidney Injury | |
dc.subject | COVID-19 | |
dc.subject | Cohort Studies | |
dc.subject | Hospital Mortality | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Prospective Studies | |
dc.subject | Retrospective Studies | |
dc.subject | Risk Factors | |
dc.subject | SARS-CoV-2 | |
dc.subject | United Kingdom | |
dc.subject | World Health Organization | |
dc.title | Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. | |
dc.type | Article | |
dc.date.updated | 2022-04-28T10:01:36Z | |
prism.endingPage | 284 | |
prism.issueIdentifier | 2 | |
prism.publicationDate | 2022 | |
prism.publicationName | Nephrol Dial Transplant | |
prism.startingPage | 271 | |
prism.volume | 37 | |
dc.identifier.doi | 10.17863/CAM.84013 | |
rioxxterms.versionofrecord | 10.1093/ndt/gfab303 | |
rioxxterms.version | VoR | |
dc.contributor.orcid | Sullivan, Michael K [0000-0002-3800-2330] | |
dc.contributor.orcid | Lees, Jennifer S [0000-0001-6331-0178] | |
dc.contributor.orcid | Semple, Malcolm G [0000-0001-9700-0418] | |
dc.contributor.orcid | Ho, Antonia [0000-0003-1465-3785] | |
dc.contributor.orcid | Mark, Patrick B [0000-0003-3387-2123] | |
dc.identifier.eissn | 1460-2385 | |
rioxxterms.type | Journal Article/Review | |
cam.issuedOnline | 2021-10-18 | |
cam.depositDate | 2022-04-28 | |
pubs.licence-identifier | apollo-deposit-licence-2-1 | |
pubs.licence-display-name | Apollo Repository Deposit Licence Agreement |
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