Genetic variation of macronutrient tolerance in Drosophila melanogaster.
Springer Science and Business Media LLC
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Havula, E., Ghazanfar, S., Lamichane, N., Francis, D., Hasygar, K., Liu, Y., Alton, L., et al. (2022). Genetic variation of macronutrient tolerance in Drosophila melanogaster.. Nat Commun, 13 (1) https://doi.org/10.1038/s41467-022-29183-x
Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
Animals, Drosophila, Drosophila melanogaster, DNA-Binding Proteins, Drosophila Proteins, Transcription Factors, Genetic Variation, Sugars, Nutrients
External DOI: https://doi.org/10.1038/s41467-022-29183-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336640
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/