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dc.contributor.authorHavula, E
dc.contributor.authorGhazanfar, S
dc.contributor.authorLamichane, N
dc.contributor.authorFrancis, D
dc.contributor.authorHasygar, K
dc.contributor.authorLiu, Y
dc.contributor.authorAlton, L A
dc.contributor.authorJohnstone, J
dc.contributor.authorNeedham, E J
dc.contributor.authorPulpitel, T
dc.contributor.authorClark, T
dc.contributor.authorNiranjan, H N
dc.contributor.authorShang, V
dc.contributor.authorTong, V
dc.contributor.authorJiwnani, N
dc.contributor.authorAudia, G
dc.contributor.authorAlves, A N
dc.contributor.authorSylow, L
dc.contributor.authorMirth, C
dc.contributor.authorNeely, G G
dc.contributor.authorYang, J
dc.contributor.authorHietakangas, V
dc.contributor.authorSimpson, S J
dc.contributor.authorSenior, A M
dc.date.accessioned2022-04-30T01:03:46Z
dc.date.available2022-04-30T01:03:46Z
dc.date.issued2022-03-28
dc.identifier.issn2041-1723
dc.identifier.other35347148
dc.identifier.otherPMC8960806
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336640
dc.description.abstractCarbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101528555
dc.sourceessn: 2041-1723
dc.subjectAnimals
dc.subjectDrosophila
dc.subjectDrosophila melanogaster
dc.subjectDNA-Binding Proteins
dc.subjectDrosophila Proteins
dc.subjectTranscription Factors
dc.subjectGenetic Variation
dc.subjectSugars
dc.subjectNutrients
dc.titleGenetic variation of macronutrient tolerance in Drosophila melanogaster.
dc.typeArticle
dc.date.updated2022-04-30T01:03:46Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume13
dc.identifier.doi10.17863/CAM.84061
rioxxterms.versionofrecord10.1038/s41467-022-29183-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidHavula, E [0000-0002-9253-5816]
dc.contributor.orcidLamichane, N [0000-0002-1746-0332]
dc.contributor.orcidFrancis, D [0000-0002-4158-1521]
dc.contributor.orcidLiu, Y [0000-0002-6419-1980]
dc.contributor.orcidAlton, L A [0000-0002-4236-2494]
dc.contributor.orcidJohnstone, J [0000-0002-8523-9269]
dc.contributor.orcidNeedham, E J [0000-0001-6326-9048]
dc.contributor.orcidJiwnani, N [0000-0001-7308-7109]
dc.contributor.orcidAudia, G [0000-0002-8957-2536]
dc.contributor.orcidAlves, A N [0000-0002-1650-8058]
dc.contributor.orcidSylow, L [0000-0003-0905-5932]
dc.contributor.orcidMirth, C [0000-0002-9765-4021]
dc.contributor.orcidNeely, G G [0000-0002-1957-9732]
dc.contributor.orcidYang, J [0000-0002-5271-2603]
dc.contributor.orcidHietakangas, V [0000-0002-9900-7549]
dc.contributor.orcidSimpson, S J [0000-0003-0256-7687]
dc.contributor.orcidSenior, A M [0000-0001-9805-7280]


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International