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dc.contributor.authorBethlehem, Richard
dc.contributor.authorSeidlitz, J
dc.contributor.authorWhite, Simon
dc.contributor.authorVogel, JW
dc.contributor.authorAnderson, KM
dc.contributor.authorAdamson, C
dc.contributor.authorAdler, S
dc.contributor.authorAlexopoulos, GS
dc.contributor.authorAnagnostou, E
dc.contributor.authorAreces-Gonzalez, A
dc.contributor.authorAstle, Duncan
dc.contributor.authorAuyeung, B
dc.contributor.authorAyub, M
dc.contributor.authorBall, G
dc.contributor.authorBaron-Cohen, Simon
dc.contributor.authorBeare, R
dc.contributor.authorBedford, SA
dc.contributor.authorBenegal, V
dc.contributor.authorBeyer, F
dc.contributor.authorBin Bae, J
dc.contributor.authorBlangero, J
dc.contributor.authorBlesa Cábez, M
dc.contributor.authorBoardman, JP
dc.contributor.authorBorzage, M
dc.contributor.authorBosch-Bayard, JF
dc.contributor.authorBourke, N
dc.contributor.authorCalhoun, VD
dc.contributor.authorChakravarty, MM
dc.contributor.authorChen, C
dc.contributor.authorChertavian, C
dc.contributor.authorChetelat, G
dc.contributor.authorChong, YS
dc.contributor.authorCole, JH
dc.contributor.authorCorvin, A
dc.contributor.authorCourchesne, E
dc.contributor.authorCrivello, F
dc.contributor.authorCropley, VL
dc.contributor.authorCrosbie, J
dc.contributor.authorCrossley, N
dc.contributor.authorDelarue, M
dc.contributor.authorDesrivieres, S
dc.contributor.authorDevenyi, G
dc.contributor.authorDi Biase, MA
dc.contributor.authorDolan, R
dc.contributor.authorDonald, KA
dc.contributor.authorDonohoe, G
dc.contributor.authorDunlop, K
dc.contributor.authorEdwards, AD
dc.contributor.authorElison, JT
dc.contributor.authorEllis, CT
dc.contributor.authorElman, JA
dc.contributor.authorEyler, L
dc.contributor.authorFair, DA
dc.contributor.authorFletcher, PC
dc.contributor.authorFonagy, P
dc.contributor.authorFranz, CE
dc.contributor.authorGalan-Garcia, L
dc.contributor.authorGholipour, A
dc.contributor.authorGiedd, J
dc.contributor.authorGilmore, JH
dc.contributor.authorGlahn, DC
dc.contributor.authorGoodyer, I
dc.contributor.authorGrant, PE
dc.contributor.authorGroenewold, NA
dc.contributor.authorGunning, FM
dc.contributor.authorGur, RE
dc.contributor.authorGur, RC
dc.contributor.authorHammill, CF
dc.contributor.authorHansson, O
dc.contributor.authorHedden, T
dc.contributor.authorHeinz, A
dc.contributor.authorHenson, Rik
dc.contributor.authorHeuer, K
dc.contributor.authorHoare, J
dc.contributor.authorHolla, B
dc.contributor.authorHolmes, AJ
dc.contributor.authorHolt, Rosemary
dc.contributor.authorHuang, H
dc.contributor.authorIm, K
dc.contributor.authorIpser, J
dc.contributor.authorJack, CR
dc.contributor.authorJackowski, AP
dc.contributor.authorJia, T
dc.contributor.authorJohnson, KA
dc.contributor.authorJones, Peter
dc.contributor.authorJones, DT
dc.contributor.authorKahn, R
dc.contributor.authorKarlsson, H
dc.contributor.authorKarlsson, L
dc.contributor.authorKawashima, R
dc.contributor.authorKelley, EA
dc.contributor.authorKern, S
dc.contributor.authorKim, K
dc.contributor.authorKitzbichler, Manfred
dc.contributor.authorKremen, WS
dc.contributor.authorLalonde, F
dc.contributor.authorLandeau, B
dc.contributor.authorLee, S
dc.contributor.authorLerch, J
dc.contributor.authorLewis, JD
dc.contributor.authorLi, J
dc.contributor.authorLiao, W
dc.contributor.authorLinares, DP
dc.contributor.authorListon, C
dc.contributor.authorLombardo, MV
dc.contributor.authorLv, J
dc.contributor.authorLynch, C
dc.contributor.authorMallard, TT
dc.contributor.authorMarcelis, M
dc.contributor.authorMarkello, RD
dc.contributor.authorMazoyer, B
dc.contributor.authorMcGuire, P
dc.contributor.authorMeaney, MJ
dc.contributor.authorMechelli, A
dc.contributor.authorMedic, N
dc.contributor.authorMisic, B
dc.contributor.authorMorgan, SE
dc.contributor.authorMothersill, D
dc.contributor.authorNigg, J
dc.contributor.authorOng, MQW
dc.contributor.authorOrtinau, C
dc.contributor.authorOssenkoppele, R
dc.contributor.authorOuyang, M
dc.contributor.authorPalaniyappan, L
dc.contributor.authorPaly, L
dc.contributor.authorPan, PM
dc.contributor.authorPantelis, C
dc.contributor.authorPark, MM
dc.contributor.authorPaus, T
dc.contributor.authorPausova, Z
dc.contributor.authorPichet Binette, A
dc.contributor.authorPierce, K
dc.contributor.authorQian, X
dc.contributor.authorQiu, J
dc.contributor.authorQiu, A
dc.contributor.authorRaznahan, A
dc.contributor.authorRittman, Timothy
dc.contributor.authorRollins, CK
dc.contributor.authorRomero-Garcia, R
dc.contributor.authorRonan, L
dc.contributor.authorRosenberg, MD
dc.contributor.authorRowitch, David
dc.contributor.authorSalum, GA
dc.contributor.authorSatterthwaite, TD
dc.contributor.authorSchaare, HL
dc.contributor.authorSchachar, RJ
dc.contributor.authorSchultz, AP
dc.contributor.authorSchumann, G
dc.contributor.authorSchöll, M
dc.contributor.authorSharp, D
dc.contributor.authorShinohara, RT
dc.contributor.authorSkoog, I
dc.contributor.authorSmyser, CD
dc.contributor.authorSperling, RA
dc.contributor.authorStein, DJ
dc.contributor.authorStolicyn, A
dc.contributor.authorSuckling, J
dc.contributor.authorSullivan, G
dc.contributor.authorTaki, Y
dc.contributor.authorThyreau, B
dc.contributor.authorToro, R
dc.contributor.authorTsvetanov, Kamen A.
dc.contributor.authorTurk-Browne, NB
dc.contributor.authorTuulari, JJ
dc.contributor.authorTzourio, C
dc.contributor.authorVachon-Presseau, É
dc.contributor.authorValdes-Sosa, MJ
dc.contributor.authorValdes-Sosa, PA
dc.contributor.authorValk, SL
dc.contributor.authorvan Amelsvoort, T
dc.contributor.authorVandekar, SN
dc.contributor.authorVasung, L
dc.contributor.authorVictoria, LW
dc.contributor.authorVilleneuve, S
dc.contributor.authorVillringer, A
dc.contributor.authorVértes, PE
dc.contributor.authorWagstyl, K
dc.contributor.authorWang, YS
dc.contributor.authorWarfield, SK
dc.contributor.authorWarrier, Varun
dc.contributor.authorWestman, E
dc.contributor.authorWestwater-Wozniak, Margaret
dc.contributor.authorWhalley, HC
dc.contributor.authorWitte, AV
dc.contributor.authorYang, N
dc.contributor.authorYeo, BTT
dc.contributor.authorYun, HJ
dc.contributor.authorZalesky, A
dc.contributor.authorZar, HJ
dc.contributor.authorZettergren, A
dc.contributor.authorZhou, JH
dc.contributor.authorZiauddeen, Hisham
dc.contributor.authorZugman, A
dc.contributor.authorZuo, XN
dc.contributor.authorAlexander-Bloch, AF
dc.contributor.authorAIBL
dc.contributor.authorAlzheimer’s Disease Neuroimaging Initiative
dc.contributor.authorAlzheimer’s Disease Repository Without Borders Investigators
dc.contributor.authorASRB
dc.contributor.authorCALM Team
dc.contributor.authorCam-CAN
dc.contributor.authorCCNP, 3R-BRAIN
dc.contributor.authorCOBRE
dc.contributor.authorENIGMA Developmental Brain Age working group
dc.contributor.authorFinnBrain
dc.contributor.authorHarvard Aging Brain Study
dc.contributor.authorIMAGEN, KNE96
dc.contributor.authorNSPN
dc.contributor.authorOASIS-3
dc.contributor.authorOpenPain Project
dc.contributor.authorPOND
dc.contributor.authorThe PREVENT-AD Research Group, VETSA, Bullmore, E.T
dc.date.accessioned2022-05-09T11:05:10Z
dc.date.available2022-05-09T11:05:10Z
dc.date.issued2022-04-06
dc.identifier.issn0028-0836
dc.identifier.other35388223
dc.identifier.otherPMC9021021
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336922
dc.descriptionFunder: Wellcome Trust
dc.description.abstractOver the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource ( www.brainchart.io ) to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study, against models of expected age-related trends. With the goal of basing these on the largest and most inclusive dataset, we aggregated MRI data spanning 115 days post-conception through 100 postnatal years, totaling 122,123 scans from 100,071 individuals in over 100 studies across 6 continents. When quantified as centile scores relative to the reference models, individual differences show high validity with non-MRI brain growth estimates and high stability across longitudinal assessment. Centile scores helped identify previously unreported brain developmental milestones and demonstrated increased genetic heritability compared to non-centiled MRI phenotypes. Crucially for the study of brain disorders, centile scores provide a standardised and interpretable measure of deviation that reveals new patterns of neuroanatomical differences across neurological and psychiatric disorders emerging during development and ageing. In sum, brain charts for the human lifespan are an essential first step towards robust, standardised quantification of individual variation and for characterizing deviation from age-related trends. Our global collaborative study provides such an anchorpoint for basic neuroimaging research and will facilitate implementation of research-based standards in clinical studies.
dc.languageeng
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 0410462
dc.sourceessn: 1476-4687
dc.subjectBrain
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectBody Height
dc.subjectLongevity
dc.subjectNeuroimaging
dc.titleBrain charts for the human lifespan
dc.typeArticle
dc.date.updated2022-05-09T11:05:10Z
prism.endingPage533
prism.issueIdentifier7906
prism.publicationNameNature
prism.startingPage525
prism.volume604
dc.identifier.doi10.17863/CAM.84341
dcterms.dateAccepted2022-02-16
rioxxterms.versionofrecord10.1038/s41586-022-04554-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBethlehem, Richard [0000-0002-0714-0685]
dc.contributor.orcidWhite, Simon [0000-0001-8642-7037]
dc.contributor.orcidAstle, Duncan [0000-0002-7042-5392]
dc.contributor.orcidBaron-Cohen, Simon [0000-0001-9217-2544]
dc.contributor.orcidHenson, Rik [0000-0002-0712-2639]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.contributor.orcidKitzbichler, Manfred [0000-0002-4494-0753]
dc.contributor.orcidRittman, Timothy [0000-0003-1063-6937]
dc.contributor.orcidRowitch, David [0000-0002-0079-0060]
dc.contributor.orcidTsvetanov, Kamen A. [0000-0002-3178-6363]
dc.contributor.orcidWestwater-Wozniak, Margaret [0000-0002-2918-0979]
dc.contributor.orcidZiauddeen, Hisham [0000-0003-4044-1719]
dc.identifier.eissn1476-4687
pubs.funder-project-idMedical Research Council (MC_UU_00005/8)
pubs.funder-project-idMedical Research Council (MC_UU_00005/2)
pubs.funder-project-idBritish Academy (PFO\170517)
pubs.funder-project-idAutism Research Trust (Unknown)
cam.issuedOnline2022-04-06


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International