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Practical Considerations for Continuous Time-Domain Cerebrovascular Reactivity Indices in Traumatic Brain Injury: Do Scaling Errors in Parent Signals Matter?

Published version
Peer-reviewed

Type

Article

Change log

Authors

Froese, Logan 
Gomez, Alwyn 
Sainbhi, Amanjyot Singh  ORCID logo  https://orcid.org/0000-0003-3231-5683
Slack, Trevor 
Zeiler, Frederick A 

Abstract

Literature pertaining to traumatic brain injury care involves the mediation and control of secondary brain injury mechanisms, chief among these is cerebral autoregulation. Cerebral autoregulation is frequently assessed through surrogate measures of cerebrovascular reactivity. An important aspect to acknowledge when calculating cerebrovascular reactivity indices is the linearity within two-parent bio-signals or variables. We highlighted the concept of linearity in raw parent bio-signals used for the calculation of the cerebrovascular reactivity index and what potential implications linearity carries for index derivation. Key of which is that the initial differencing or location of the pressure probes does not influence linear methods of cerebral reactivity calculations so long as the slow-wave vasogenic changes are being recorded.

Description

Keywords

Traumatic brain injury, Cerebral Autoregulation, Linearity, Continuous Monitoring, Cerebrovascular Reactivity (Cvrx)

Journal Title

Frontiers in neurology

Conference Name

Journal ISSN

1664-2295

Volume Title

13

Publisher