Practical Considerations for Continuous Time-Domain Cerebrovascular Reactivity Indices in Traumatic Brain Injury: Do Scaling Errors in Parent Signals Matter?
Zeiler, Frederick A
Frontiers in neurology
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Froese, L., Gomez, A., Sainbhi, A. S., Slack, T., & Zeiler, F. A. (2022). Practical Considerations for Continuous Time-Domain Cerebrovascular Reactivity Indices in Traumatic Brain Injury: Do Scaling Errors in Parent Signals Matter?. Frontiers in neurology, 13 https://doi.org/10.3389/fneur.2022.857617
Literature pertaining to traumatic brain injury care involves the mediation and control of secondary brain injury mechanisms, chief among these is cerebral autoregulation. Cerebral autoregulation is frequently assessed through surrogate measures of cerebrovascular reactivity. An important aspect to acknowledge when calculating cerebrovascular reactivity indices is the linearity within two-parent bio-signals or variables. We highlighted the concept of linearity in raw parent bio-signals used for the calculation of the cerebrovascular reactivity index and what potential implications linearity carries for index derivation. Key of which is that the initial differencing or location of the pressure probes does not influence linear methods of cerebral reactivity calculations so long as the slow-wave vasogenic changes are being recorded.
Traumatic brain injury, Cerebral Autoregulation, Linearity, Continuous Monitoring, Cerebrovascular Reactivity (Cvrx)
External DOI: https://doi.org/10.3389/fneur.2022.857617
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336923
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/