An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia.
View / Open Files
Authors
Ferkol, Thomas
Colas, Murielle
Davis, Stephanie D
Haarman, Eric
Hogg, Claire
Kilbride, Emma
Marangu, Diana
Nielsen, Kim G
Rumman, Nisreen
Rutter, Matthew
Walker, Woolf
Publication Date
2022-04Journal Title
ERJ Open Res
ISSN
2312-0541
Publisher
European Respiratory Society (ERS)
Volume
8
Issue
2
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Beydon, N., Ferkol, T., Harris, A. L., Colas, M., Davis, S. D., Haarman, E., Hogg, C., et al. (2022). An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia.. ERJ Open Res, 8 (2) https://doi.org/10.1183/23120541.00708-2021
Abstract
Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of having primary ciliary dyskinesia (PCD), but recommendations for performing such measurements have not focused on children and do not include all current practices. To guide the development of a European Respiratory Society-supported technical standard for nNO measurement in children, an international online survey was conducted to better understand current measurement practices among providers involved in PCD diagnostics. 78 professionals responded, representing 65 centres across 18 countries, mainly in Europe and North America. Nearly all centres measured nNO in children and more than half performed measurements before 5 years of age. The test was often postponed in children with signs of acute airway infection. In Europe, the electrochemical technique was more frequently used than chemiluminescence. A similar proportion of centres performed measurements during exhalation against a resistance (49 out of 65) or during tidal breathing (50 out of 65); 15 centres used only exhalation against a resistance and 15 used only tidal breathing. The cut-off values used to discriminate PCD were consistent across centres using chemiluminescence analysers; these centres reported results as an output (nL·min-1). Cut-off values were highly variable across centres using electrochemical devices, and nNO concentrations were typically reported as ppb. This survey is the first to determine real-world use of nNO measurements globally and revealed remarkable variability in methodology, equipment and interpretation. These findings will help standardise methods and training.
Identifiers
35386825, PMC8977594
External DOI: https://doi.org/10.1183/23120541.00708-2021
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336925
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk