THE EXTRACELLULAR MATRIX AND PERINEURONAL NETS IN MEMORY
View / Open Files
Journal Title
Molecular Psychiatry
ISSN
1359-4184
Publisher
Springer Nature [academic journals on nature.com]
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Fawcett, J., Kwok, J., Ruzicka, J., Jendelova, P., Fyhn, M., & Sorg, B. THE EXTRACELLULAR MATRIX AND PERINEURONAL NETS IN MEMORY. Molecular Psychiatry https://doi.org/10.17863/CAM.84384
Abstract
Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store, and that they which remains stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naïve animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage.
Sponsorship
Funding for this research came from: Center of Reconstruction Neuroscience – NEURORECON CZ.02.1.01/0.0/0.0/15_003/0000419 and Czech Science Agency 19-10365S. Medical Research Council MR/R004463, MR/V002694, Wings for Life (WFL-GB-04/19), IRP P172 to JWF. Epilepsy Research UK (P1807), Alzheimer’s Research UK, Wings for Life (WFL-UK-008-15), COST Action INNOGLY (CA18103) to JCFK. Good Samaritan Foundation of Legacy Health, and National Institutes of Health DA040965 and DA047121 to BAS.
Funder references
Medical Research Council (MR/R004544/1)
Embargo Lift Date
2025-05-09
Identifiers
This record's DOI: https://doi.org/10.17863/CAM.84384
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336961
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.