Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?
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Publication Date
2022-05-11Journal Title
J Virol
ISSN
0022-538X
Publisher
American Society for Microbiology
Volume
96
Issue
9
Language
eng
Type
Article
This Version
VoR
Metadata
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Pley, C., Lourenço, J., McNaughton, A. L., & Matthews, P. C. (2022). Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?. J Virol, 96 (9) https://doi.org/10.1128/jvi.00051-22
Description
Funder: NIHR | NIHR Oxford Biomedical Research Centre
Funder: NIHR | NIHR Oxford Biomedical Research Centre (OxBRC)
Abstract
Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes.
Keywords
Polymorphism, Evolution, Genotype, Hepatitis B virus, Phylogeny, Diversity, HBV, Polymerase, Spacer
Sponsorship
Wellcome Trust (110110/Z/15/Z)
Identifiers
35412348, PMC9093120
External DOI: https://doi.org/10.1128/jvi.00051-22
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337158
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