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dc.contributor.authorLopez-Gomollon, Sara
dc.contributor.authorMüller, Sebastian Y
dc.contributor.authorBaulcombe, David C
dc.date.accessioned2022-05-18T23:30:25Z
dc.date.available2022-05-18T23:30:25Z
dc.date.issued2022-05-21
dc.identifier.issn1474-7596
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337287
dc.description.abstractBACKGROUND: Hybridization is associated with the activation of transposable elements and changes in the patterns of gene expression leading to phenotypic changes. However, the underlying mechanisms are not well understood. RESULTS: Here, we describe the changes to the gene expression in interspecific Solanum hybrids that are associated with small RNAs derived from endogenous (para)retroviruses (EPRV). There were prominent changes to sRNA profiles in these hybrids involving 22-nt species produced in the DCL2 biogenesis pathway, and the hybridization-induced changes to the gene expression were similar to those in a dcl2 mutant. CONCLUSIONS: These findings indicate that hybridization leads to activation of EPRV, perturbation of small RNA profiles, and, consequently, changes in the gene expression. Such hybridization-induced variation in the gene expression could increase the natural phenotypic variation in natural evolution or in breeding for agriculture.
dc.description.sponsorshipThis work was supported by the European Research Council Advanced Investigator grant ERC-2013-AdG 340642 (Transgressive Inheritance in Plant Breeding and Evolution [TRIBE]), the Royal Society (RP170001), Syngenta, the Biotechnology and Biological Sciences Research Council (RG68461), the Balzan Foundation, and the Broodbank Fund. SLG is a Senior Broodbank Research Fellow. D.C.B. is the Royal Society Edward Penley Abraham Research Professor.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleInterspecific hybridization in tomato influences endogenous viral sRNAs and alters gene expression.
dc.typeArticle
dc.publisher.departmentDepartment of Plant Sciences
dc.date.updated2022-05-17T10:49:53Z
prism.publicationNameGenome Biol
dc.identifier.doi10.17863/CAM.84702
dcterms.dateAccepted2022-05-09
rioxxterms.versionofrecord10.1186/s13059-022-02685-z
rioxxterms.versionVoR
dc.contributor.orcidLopez-Gomollon, Sara [0000-0001-8504-0340]
dc.contributor.orcidMüller, Sebastian Y [0000-0002-0148-7020]
dc.contributor.orcidBaulcombe, David C [0000-0003-0780-6878]
dc.identifier.eissn1474-760X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idRoyal Society (RP120015)
pubs.funder-project-idEuropean Research Council (233325)
pubs.funder-project-idEuropean Research Council (340642)
pubs.funder-project-idRoyal Society (RP170001)
cam.issuedOnline2022-05-21
datacite.issupplementedby.doidoi.org/10.1186/s13059-022-02685-z.
cam.orpheus.success2022-05-24: VoR added to Apollo record
cam.depositDate2022-05-17
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International