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dc.contributor.authorMcMurran, Christopher E.
dc.contributor.authorMukherjee, Trisha
dc.contributor.authorBrown, James W. L.
dc.contributor.authorMichell, Andrew W.
dc.contributor.authorChard, Declan T.
dc.contributor.authorFranklin, Robin J. M.
dc.contributor.authorColes, Alasdair J.
dc.contributor.authorCunniffe, Nick G.
dc.date.accessioned2022-05-19T17:00:05Z
dc.date.available2022-05-19T17:00:05Z
dc.date.issued2022-05-19
dc.date.submitted2022-03-01
dc.identifier.issn2328-9503
dc.identifier.otheracn351595
dc.identifier.otheracn3-2022-03-0106-bc.r1
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337313
dc.descriptionFunder: Cambridge NIHR Biomedical Centre
dc.descriptionFunder: Cambridge NIHR Clinical Research Facility
dc.description.abstractAbstract: Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked potential latency in patients with chronic optic neuropathy aged under 42 years only (with the effect diminishing by 0.45 ms per year of age); and increased the magnetization transfer ratio of deep gray matter lesions in those under 43 years only. Addressing this age‐related decline in human remyelination capacity will be an important step in the development of remyelinating therapies that work across the lifespan.
dc.languageen
dc.subjectBrief Communication
dc.subjectBrief Communications
dc.titleRemyelination in humans due to a retinoid‐X receptor agonist is age‐dependent
dc.typeOther
dc.date.updated2022-05-19T17:00:04Z
prism.publicationNameAnnals of Clinical and Translational Neurology
dc.identifier.doi10.17863/CAM.84726
dcterms.dateAccepted2022-05-10
rioxxterms.versionofrecord10.1002/acn3.51595
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMcMurran, Christopher E. [0000-0002-8710-0930]
dc.contributor.orcidBrown, James W. L. [0000-0002-7737-5834]
dc.contributor.orcidColes, Alasdair J. [0000-0003-4738-0760]
pubs.funder-project-idUK Multiple Sclerosis Society (RRZD/004 Task 3 Sub‐contracting (RG59911))


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