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dc.contributor.authorDe Belly, Henry
dc.contributor.authorPaluch, Ewa K
dc.contributor.authorChalut, Kevin J
dc.date.accessioned2022-05-19T23:30:06Z
dc.date.available2022-05-19T23:30:06Z
dc.date.issued2022-07
dc.identifier.issn1471-0072
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337317
dc.description.abstractMechanical signalling affects multiple biological processes during development and in adult organisms, including cell fate transitions, cell migration, morphogenesis and immune responses. Here, we review recent insights into the mechanisms and functions of two main routes of mechanical signalling: outside-in mechanical signalling, such as mechanosensing of substrate properties or shear stresses; and mechanical signalling regulated by the physical properties of the cell surface itself. We discuss examples of how these two classes of mechanical signalling regulate stem cell function, as well as developmental processes in vivo. We also discuss how cell surface mechanics affects intracellular signalling and, in turn, how intracellular signalling controls cell surface mechanics, generating feedback into the regulation of mechanosensing. The cooperation between mechanosensing, intracellular signalling and cell surface mechanics has a profound impact on biological processes. We discuss here our understanding of how these three elements interact to regulate stem cell fate and development.
dc.format.mediumPrint-Electronic
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleInterplay between mechanics and signalling in regulating cell fate.
dc.typeArticle
dc.publisher.departmentDepartment of Physiology, Development And Neuroscience
dc.publisher.departmentDepartment of Haematology
dc.date.updated2022-05-11T10:14:11Z
prism.endingPage16
prism.publicationDate2022
prism.publicationNameNat Rev Mol Cell Biol
prism.startingPage1
dc.identifier.doi10.17863/CAM.84731
dcterms.dateAccepted2022-03-04
rioxxterms.versionofrecord10.1038/s41580-022-00472-z
rioxxterms.versionAM
dc.contributor.orcidPaluch, Ewa K [0000-0003-4691-2323]
dc.contributor.orcidChalut, Kevin J [0000-0001-6200-9690]
dc.identifier.eissn1471-0080
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (772798)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (641639)
pubs.funder-project-idEuropean Research Council (820188)
cam.issuedOnline2022-04
cam.orpheus.success2022-05-19 - Embargo set during processing via Fast-track
cam.depositDate2022-05-11
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-10-01


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