Could targeting the macrophage urokinase-type plasminogen activator receptor be a bullseye for PET imaging of atherosclerotic plaque inflammation?
Authors
Tarkin, Jason M
Gonçalves, Isabel
Change log
Abstract
A myriad of imaging techniques and targets have been tested to identify high-risk plaques and ultimately improve patient cardiovascular risk-stratification [1]. In this issue of Atherosclerosis, Khare et al. examine the urokinase-type plasminogen activator receptor (uPAR) as a novel positron emission tomography (PET) imaging target in atherosclerosis [2]. The findings of this initial proof-of-concept study are intriguing: could targeting uPAR be a bullseye for PET imaging of atherosclerotic plaque inflammation?
Publication Date
2022-07
Online Publication Date
2022-05-18
Acceptance Date
2022-05-12
Keywords
Atherosclerosis, Inflammation, Positron emission tomography, Urokinase-type plasminogen activator receptor, Humans, Inflammation, Macrophages, Plaque, Atherosclerotic, Positron-Emission Tomography, Receptors, Urokinase Plasminogen Activator, Urokinase-Type Plasminogen Activator
Journal Title
Atherosclerosis
Journal ISSN
0021-9150
1879-1484
1879-1484
Volume Title
Publisher
Elsevier BV
Sponsorship
Wellcome Trust (211100/Z/18/Z)