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dc.contributor.authorHunter, Michael
dc.contributor.authorFusco, Diana
dc.date.accessioned2022-05-20T19:02:28Z
dc.date.available2022-05-20T19:02:28Z
dc.date.issued2022-05
dc.date.submitted2021-12-10
dc.identifier.issn1553-734X
dc.identifier.otherpcompbiol-d-21-02234
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337354
dc.description.abstractViral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral population remains unclear. Using stochastic simulations, we find that genetic drift is suppressed when superinfection occurs, thus facilitating the fixation of beneficial mutations and the removal of deleterious ones. Interestingly, we also find that the competitive (dis)advantage associated with variations in life history parameters is not necessarily captured by the viral growth rate for either infection strategy. Putting these together, we then show that a mutant with superinfection exclusion will easily overtake a superinfecting population even if the latter has a much higher growth rate. Our findings suggest that while superinfection exclusion can negatively impact the long-term adaptation of a viral population, in the short-term it is ultimately a winning strategy.
dc.languageen
dc.publisherPublic Library of Science (PLoS)
dc.subjectResearch Article
dc.subjectBiology and life sciences
dc.subjectMedicine and health sciences
dc.subjectPhysical sciences
dc.subjectResearch and analysis methods
dc.titleSuperinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks.
dc.typeArticle
dc.date.updated2022-05-20T19:02:28Z
prism.issueIdentifier5
prism.publicationNamePLoS Comput Biol
prism.volume18
dc.identifier.doi10.17863/CAM.84768
dcterms.dateAccepted2022-04-20
rioxxterms.versionofrecord10.1371/journal.pcbi.1010125
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Illingworth, Christopher
dc.contributor.orcidHunter, Michael [0000-0001-5439-2896]
dc.contributor.orcidFusco, Diana [0000-0002-1505-7160]
dc.identifier.eissn1553-7358
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/P020259/1)
cam.issuedOnline2022-05-10


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