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dc.contributor.authorYuan, Shuai
dc.contributor.authorMason, Amy M
dc.contributor.authorBurgess, Stephen
dc.contributor.authorLarsson, Susanna C
dc.date.accessioned2022-05-20T23:30:13Z
dc.date.available2022-05-20T23:30:13Z
dc.date.issued2022-10-01
dc.identifier.issn0012-1797
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337357
dc.description.abstractWe conducted a Mendelian randomization analysis to differentiate associations of four glycemic indicators with a broad range of atherosclerotic and thrombotic diseases. Independent genetic variants associated with fasting glucose (FG), 2 h glucose after an oral glucose challenge (2hGlu), fasting insulin (FI), and glycated hemoglobin (HbA1c) at the genome-wide significance threshold were used as instrumental variables. Summary-level data for 12 atherosclerotic and 4 thrombotic outcomes were obtained from large genetic consortia and the FinnGen and UK Biobank studies. Higher levels of genetically predicted glycemic traits were consistently associated with increased risk of coronary atherosclerosis-related diseases and symptoms. Genetically predicted glycemic traits except HbA1c showed positive associations with peripheral artery disease risk. Genetically predicted FI levels were positively associated with risk of ischemic stroke and chronic kidney disease. Genetically predicted FG and 2hGlu were positively associated with risk of large artery stroke. Genetically predicted 2hGlu levels showed positive associations with risk of small vessel stroke. Higher levels of genetically predicted glycemic traits were not associated with increased risk of thrombotic outcomes. Most associations for genetically predicted levels of 2hGlu and FI remained after adjustment for other glycemic traits. Increase in glycemic status appears to increase risks of coronary and peripheral artery atherosclerosis but not thrombosis.
dc.format.mediumPrint-Electronic
dc.publisherAmerican Diabetes Association
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleDifferentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation.
dc.typeArticle
dc.publisher.departmentMrc Biostatistics Unit
dc.date.updated2022-05-20T09:09:31Z
prism.publicationDate2022
prism.publicationNameDiabetes
dc.identifier.doi10.17863/CAM.84771
dcterms.dateAccepted2022-04-04
rioxxterms.versionofrecord10.2337/db21-0905
rioxxterms.versionAM
dc.contributor.orcidYuan, Shuai [0000-0001-5055-5627]
dc.contributor.orcidLarsson, Susanna C [0000-0003-0118-0341]
dc.identifier.eissn1939-327X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (204623/Z/16/Z)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (RG/18/13/33946)
pubs.funder-project-idMedical Research Council (MC_UU_00002/7)
pubs.funder-project-idNational Institute for Health Research (IS-BRC-1215-20014)
cam.issuedOnline2022-05-02
cam.orpheus.success2022-05-20 - Embargo set during processing via Fast-track
cam.depositDate2022-05-20
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-05-02


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