'Know thyself' - host factors influencing cancer response to immune checkpoint inhibitors.
Authors
Klein, Oliver
Lawley, Trevor D
Publication Date
2022-04-08Journal Title
J Pathol
ISSN
0022-3417
Publisher
Wiley
Language
en
Type
Article
This Version
AO
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Gunjur, A., Manrique-Rincón, A. J., Klein, O., Behren, A., Lawley, T. D., Welsh, S., & Adams, D. J. (2022). 'Know thyself' - host factors influencing cancer response to immune checkpoint inhibitors.. J Pathol https://doi.org/10.1002/path.5907
Description
Funder: General Sir John Monash Foundation; Id: http://dx.doi.org/10.13039/501100017475
Funder: Victorian Cancer Agency; Id: http://dx.doi.org/10.13039/100008018
Abstract
Immune checkpoint inhibitors (ICIs) have revolutionised oncology and are now standard-of-care for the treatment of a wide variety of solid neoplasms. However, tumour responses remain unpredictable, experienced by only a minority of ICI recipients across malignancy types. Therefore, there is an urgent need for better predictive biomarkers to identify a priori the patients most likely to benefit from these therapies. Despite considerable efforts, only three such biomarkers are FDA-approved for clinical use, and all rely on the availability of tumour tissue for immunohistochemical staining or genomic assays. There is emerging evidence that host factors - for example, genetic, metabolic, and immune factors, as well as the composition of one's gut microbiota - influence the response of a patient's cancer to ICIs. Tantalisingly, some of these factors are modifiable, paving the way for co-therapies that may enhance the therapeutic index of these treatments. Herein, we review key host factors that are of potential biomarker value for response to ICI therapy, with a particular focus on the proposed mechanisms for these influences. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Keywords
INVITED REVIEW, INVITED REVIEWS, immune checkpoint inhibitors, immunotherapy, biomarkers, predictive, host, germline, immune system, microbiome, metabolome
Sponsorship
Cancer Research UK (A25117)
Identifiers
path5907
External DOI: https://doi.org/10.1002/path.5907
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337361
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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