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dc.contributor.authorDempsey, Paddy
dc.contributor.authorMusicha, Crispin
dc.contributor.authorRowlands, Alex V
dc.contributor.authorDavies, Melanie
dc.contributor.authorKhunti, Kamlesh
dc.contributor.authorRazieh, Cameron
dc.contributor.authorTimmins, Iain
dc.contributor.authorZaccardi, Francesco
dc.contributor.authorCodd, Veryan
dc.contributor.authorNelson, Christopher P
dc.contributor.authorYates, Tom
dc.contributor.authorSamani, Nilesh J
dc.date.accessioned2022-05-23T01:02:41Z
dc.date.available2022-05-23T01:02:41Z
dc.date.issued2022-04-20
dc.identifier.issn2399-3642
dc.identifier.other35444173
dc.identifier.otherPMC9021230
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337384
dc.description.abstractWalking pace is a simple and functional form of movement and a strong predictor of health status, but the nature of its association with leucocyte telomere length (LTL) is unclear. Here we investigate whether walking pace is associated with LTL, which is causally associated with several chronic diseases and has been proposed as a marker of biological age. Analyses were conducted in 405,981 UK Biobank participants. We show that steady/average and brisk walkers had significantly longer LTL compared with slow walkers, with accelerometer-assessed measures of physical activity further supporting this through an association between LTL and habitual activity intensity, but not with total amount of activity. Bi-directional mendelian randomisation analyses suggest a causal link between walking pace and LTL, but not the other way around. A faster walking pace may be causally associated with longer LTL, which could help explain some of the beneficial effects of brisk walking on health status. Given its simple measurement and low heritability, self-reported walking pace may be a pragmatic target for interventions.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101719179
dc.sourceessn: 2399-3642
dc.subjectTelomere
dc.subjectHumans
dc.subjectBiological Specimen Banks
dc.subjectSelf Report
dc.subjectUnited Kingdom
dc.subjectWalking Speed
dc.titleInvestigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length.
dc.typeArticle
dc.date.updated2022-05-23T01:02:41Z
prism.issueIdentifier1
prism.publicationNameCommun Biol
prism.volume5
dc.identifier.doi10.17863/CAM.84798
dcterms.dateAccepted2022-03-25
rioxxterms.versionofrecord10.1038/s42003-022-03323-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidDempsey, Paddy [0000-0002-1714-6087]
dc.contributor.orcidRazieh, Cameron [0000-0003-3597-2945]
dc.contributor.orcidTimmins, Iain [0000-0002-8761-582X]
dc.identifier.eissn2399-3642
pubs.funder-project-idMedical Research Council (MR/M012816/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idMRC (MC_UU_00006/4)
cam.issuedOnline2022-04-20


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International