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dc.contributor.authorLurette, Olivier
dc.contributor.authorGuedouari, Hala
dc.contributor.authorMorris, Jordan L
dc.contributor.authorMartín-Jiménez, Rebeca
dc.contributor.authorRobichaud, Julie-Pier
dc.contributor.authorHamel-Côté, Geneviève
dc.contributor.authorKhan, Mehtab
dc.contributor.authorDauphinee, Nicholas
dc.contributor.authorPichaud, Nicolas
dc.contributor.authorPrudent, Julien
dc.contributor.authorHebert-Chatelain, Etienne
dc.date.accessioned2022-05-23T23:30:22Z
dc.date.available2022-05-23T23:30:22Z
dc.date.issued2022-05-30
dc.identifier.issn1420-682X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337410
dc.description.abstractThe architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress. Understanding how these events are regulated is important to elucidate how mitochondrial dynamics control cell fate. Here, we show that the tyrosine kinase Src regulates mitochondrial morphology. Deletion of Src increased mitochondrial size and reduced cellular respiration independently of mitochondrial mass, mitochondrial membrane potential or ATP levels. Re-expression of Src targeted to the mitochondrial matrix, but not of Src targeted to the plasma membrane, rescued mitochondrial morphology in a kinase activity-dependent manner. These findings highlight a novel function for Src in the control of mitochondrial dynamics.
dc.publisherSpringer
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleMitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
dc.typeArticle
dc.publisher.departmentMrc Mitochondrial Biology Unit
dc.date.updated2022-05-20T14:37:56Z
prism.publicationNameCell Mol Life Sci
dc.identifier.doi10.17863/CAM.84822
dcterms.dateAccepted2022-04-22
rioxxterms.versionofrecord10.1007/s00018-022-04325-y
rioxxterms.versionAM
dc.contributor.orcidPrudent, Julien [0000-0003-3821-6088]
dc.contributor.orcidHebert-Chatelain, Etienne [0000-0003-1480-2787]
dc.identifier.eissn1420-9071
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MC_UU_00015/7)
pubs.funder-project-idMedical Research Council (MC_UU_00015/7)
cam.orpheus.successWed Jun 08 08:57:24 BST 2022 - Embargo updated*
cam.orpheus.counter1
cam.depositDate2022-05-20
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-05-30


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