SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases.
View / Open Files
Authors
Iles, Jason
Gardiner, Anna
Lacey, Jonathan
Harding, Stephen
Ule, Jernej
Roblett, Debra
Heeney, Jonathan
Baxendale, Helen
Publication Date
2022-04-08Journal Title
International journal of molecular sciences
ISSN
1422-0067
Volume
23
Issue
8
Language
eng
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Iles, J., Zmuidinaite, R., Sadee, C., Gardiner, A., Lacey, J., Harding, S., Ule, J., et al. (2022). SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases.. International journal of molecular sciences, 23 (8) https://doi.org/10.3390/ijms23084126
Abstract
The immune response to SARS-CoV-2 infection requires antibody recognition of the spike protein. In a study designed to examine the molecular features of anti-spike and anti-nucleocapsid antibodies, patient plasma proteins binding to pre-fusion stabilised complete spike and nucleocapsid proteins were isolated and analysed by matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry. Amongst the immunoglobulins, a high affinity for human serum albumin was evident in the anti-spike preparations. Careful mass comparison revealed the preferential capture of advanced glycation end product (AGE) forms of glycated human serum albumin by the pre-fusion spike protein. The ability of bacteria and viruses to surround themselves with serum proteins is a recognised immune evasion and pathogenic process. The preference of SARS-CoV-2 for AGE forms of glycated serum albumin may in part explain the severity and pathology of acute respiratory distress and the bias towards the elderly and those with (pre)diabetic and atherosclerotic/metabolic disease.
Keywords
Humans, Diabetes Mellitus, Type 2, Prediabetic State, Serum Albumin, Antibodies, Viral, Aged, Spike Glycoprotein, Coronavirus, Serum Albumin, Human, COVID-19, SARS-CoV-2
Identifiers
35456942, PMC9030890
External DOI: https://doi.org/10.3390/ijms23084126
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337451
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.