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dc.contributor.authorAllain, Jean-Pierre
dc.contributor.authorOwusu-Ofori, Shirley
dc.contributor.authorYe, Xianlin
dc.contributor.authorBisseye, Cyrille
dc.contributor.authorChaar, Mira El
dc.contributor.authorLi, Chengyao
dc.date.accessioned2022-05-25T01:04:52Z
dc.date.available2022-05-25T01:04:52Z
dc.date.issued2022-03-24
dc.identifier.issn1999-4915
dc.identifier.other35458403
dc.identifier.otherPMC9029447
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337452
dc.description.abstractImmune control of various infectious diseases, particularly viral, was shown to be more efficient for females than males. Response to viral vaccines (HAV, HBV) was higher in females. Data on hepatitis B virus (HBV) markers accumulated over 15 years in blood donors was stratified according to sex, including HBsAg, HBV viral load and levels of anti-HBs in areas where genotypes B and C (China), genotype D (Iran, Lebanon, Tunisia) and genotype E (Ghana, Burkina Faso, Gabon) were prevalent. HBsAg was screened by either ELISA or rapid tests, anti-HBc and anti-HBs by ELISA, HBV DNA load by a standardized method across sites. In Ghanaian children less than 5 years, HBV DNA load was significantly lower in females than in males (p = 0.035). In China, Ghana, Burkina Faso and Gabon blood donors, median HBsAg prevalence was ~5% and 3% in China, ~8.5% and 4.5% in Gabon, ~16% and 11% in Burkina Faso and ~11% and 7% in Ghana for male and female donors, respectively (p < 0.001). In HBsAg+ Ghanaian blood donors, distribution and median viral load were not significantly different between sexes; occult hepatitis B infections (OBI) were significantly more frequent in males. In Chinese blood donor anti-HBc+ and anti-HBs+, anti-HBs levels tended to be higher in males but vaccinated donors' anti-HBs+ only, while anti-HBs levels were females > males. In areas where genotypes B-E are dominant, the prevalence of chronic HBV infection (HBsAg+) seems better controlled before age 16-18 by females infected vertically or horizontally. OBIs appear considerably more frequent in men, suggesting lower efficacy of HBV infection control. Female blood donors appear significantly safer from HBV than males, and their donation should be encouraged.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101509722
dc.sourceessn: 1999-4915
dc.subjectHumans
dc.subjectHepatitis B virus
dc.subjectHepatitis B
dc.subjectHepatitis B, Chronic
dc.subjectDNA, Viral
dc.subjectHepatitis B Antibodies
dc.subjectHepatitis B Core Antigens
dc.subjectHepatitis B Surface Antigens
dc.subjectPrevalence
dc.subjectAdolescent
dc.subjectChild
dc.subjectBlood Donors
dc.subjectGhana
dc.subjectFemale
dc.subjectMale
dc.subjectPersistent Infection
dc.titleHepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas: Comparison According to Sex.
dc.typeArticle
dc.date.updated2022-05-25T01:04:51Z
prism.issueIdentifier4
prism.publicationNameViruses
prism.volume14
dc.identifier.doi10.17863/CAM.84865
dcterms.dateAccepted2022-03-21
rioxxterms.versionofrecord10.3390/v14040673
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBisseye, Cyrille [0000-0002-6888-6317]
dc.contributor.orcidChaar, Mira El [0000-0002-8889-4234]
dc.identifier.eissn1999-4915
cam.issuedOnline2022-03-24


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International