Characterising genome architectures using genome decomposition analysis.

Authors
Aunin, Eerik 
Berriman, Matthew 
Reid, Adam James 

Change log
Abstract

Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression. We present a new tool called Genome Decomposition Analysis (GDA) that characterises genome architectures and acts as an accessible approach for discovering hidden features of a genome assembly. With the imminent deluge of high-quality genome assemblies from projects such as the Darwin Tree of Life and the Earth BioGenome Project, GDA has been designed to facilitate their exploration and the discovery of novel genome biology. We highlight the effectiveness of our approach in characterising the genome architectures of single-celled eukaryotic parasites from the phylum Apicomplexa and show that it scales well to large genomes.

Publication Date
2022-05-25
Online Publication Date
2022-05-25
Acceptance Date
2022-05-10
Keywords
Apicomplexa, Chromosome structure, Genome architecture, Genome assembly, Parasites, Plasmodium, Animals, Apicomplexa, Biological Evolution, Eukaryota, Genome, Parasites
Journal Title
BMC Genomics
Journal ISSN
1471-2164
1471-2164
Volume Title
23
Publisher
Springer Science and Business Media LLC
Sponsorship
Wellcome (206194/Z/17/Z, 206194/Z/17/Z, 206194/Z/17/Z)