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Characterising genome architectures using genome decomposition analysis.

Published version
Peer-reviewed

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Authors

Aunin, Eerik 
Berriman, Matthew 
Reid, Adam James 

Abstract

Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression. We present a new tool called Genome Decomposition Analysis (GDA) that characterises genome architectures and acts as an accessible approach for discovering hidden features of a genome assembly. With the imminent deluge of high-quality genome assemblies from projects such as the Darwin Tree of Life and the Earth BioGenome Project, GDA has been designed to facilitate their exploration and the discovery of novel genome biology. We highlight the effectiveness of our approach in characterising the genome architectures of single-celled eukaryotic parasites from the phylum Apicomplexa and show that it scales well to large genomes.

Description

Keywords

Apicomplexa, Chromosome structure, Genome architecture, Genome assembly, Parasites, Plasmodium, Animals, Apicomplexa, Biological Evolution, Eukaryota, Genome, Parasites

Journal Title

BMC Genomics

Conference Name

Journal ISSN

1471-2164
1471-2164

Volume Title

23

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome (206194/Z/17/Z, 206194/Z/17/Z, 206194/Z/17/Z)