Characterising genome architectures using genome decomposition analysis.
Authors
Aunin, Eerik
Berriman, Matthew
Reid, Adam James
Publication Date
2022-05-25Journal Title
BMC Genomics
ISSN
1471-2164
Publisher
Springer Science and Business Media LLC
Volume
23
Issue
1
Language
en
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Aunin, E., Berriman, M., & Reid, A. J. (2022). Characterising genome architectures using genome decomposition analysis.. BMC Genomics, 23 (1) https://doi.org/10.1186/s12864-022-08616-3
Abstract
Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression. We present a new tool called Genome Decomposition Analysis (GDA) that characterises genome architectures and acts as an accessible approach for discovering hidden features of a genome assembly. With the imminent deluge of high-quality genome assemblies from projects such as the Darwin Tree of Life and the Earth BioGenome Project, GDA has been designed to facilitate their exploration and the discovery of novel genome biology. We highlight the effectiveness of our approach in characterising the genome architectures of single-celled eukaryotic parasites from the phylum Apicomplexa and show that it scales well to large genomes.
Keywords
Research, Genome architecture, Chromosome structure, Genome assembly, Parasites, Apicomplexa, Plasmodium
Sponsorship
Wellcome (206194/Z/17/Z, 206194/Z/17/Z, 206194/Z/17/Z)
Identifiers
s12864-022-08616-3, 8616
External DOI: https://doi.org/10.1186/s12864-022-08616-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337471
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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