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dc.contributor.authorAunin, Eerik
dc.contributor.authorBerriman, Matthew
dc.contributor.authorReid, Adam James
dc.date.accessioned2022-05-25T15:00:51Z
dc.date.available2022-05-25T15:00:51Z
dc.date.issued2022-05-25
dc.date.submitted2021-12-15
dc.identifier.issn1471-2164
dc.identifier.others12864-022-08616-3
dc.identifier.other8616
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337471
dc.description.abstractGenome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression. We present a new tool called Genome Decomposition Analysis (GDA) that characterises genome architectures and acts as an accessible approach for discovering hidden features of a genome assembly. With the imminent deluge of high-quality genome assemblies from projects such as the Darwin Tree of Life and the Earth BioGenome Project, GDA has been designed to facilitate their exploration and the discovery of novel genome biology. We highlight the effectiveness of our approach in characterising the genome architectures of single-celled eukaryotic parasites from the phylum Apicomplexa and show that it scales well to large genomes.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectResearch
dc.subjectGenome architecture
dc.subjectChromosome structure
dc.subjectGenome assembly
dc.subjectParasites
dc.subjectApicomplexa
dc.subjectPlasmodium
dc.titleCharacterising genome architectures using genome decomposition analysis.
dc.typeArticle
dc.date.updated2022-05-25T15:00:50Z
prism.issueIdentifier1
prism.publicationNameBMC Genomics
prism.volume23
dc.identifier.doi10.17863/CAM.84885
dcterms.dateAccepted2022-05-10
rioxxterms.versionofrecord10.1186/s12864-022-08616-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1471-2164
pubs.funder-project-idWellcome (206194/Z/17/Z, 206194/Z/17/Z, 206194/Z/17/Z)
cam.issuedOnline2022-05-25


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