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Cross-sectional and longitudinal associations between psychotic and depressive symptoms in depressed adolescents.

Published version
Peer-reviewed

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Type

Article

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Authors

Kehinde, Fiona 
Bharmal, Aamena Valiji 
Goodyer, Ian M 
Kelvin, Raphael 
Dubicka, Bernadka 

Abstract

Adults with major depressive disorder (MDD) with psychotic features (delusions and/or hallucinations) have more severe symptoms and a worse prognosis. Subclinical psychotic symptoms are more common in adolescents than adults. However, the effects of psychotic symptoms on outcome of depressive symptoms have not been well studied in adolescents. Depressed adolescents aged 11-17 with and without psychotic symptoms were compared on depression severity scores at baseline and at 28- or 42-week follow-up in two large UK cohorts. Psychotic symptoms were weakly associated with more severe depression at baseline in both cohorts. At follow-up, baseline psychotic symptoms were only associated with depressive symptoms in one sample; in the other, the effect size was close to zero. This supports the DSM5 system of psychotic symptoms being a separate code to severity rather than the ICD10 system which only allows the diagnosis of psychotic depression with severe depression. There was no clear support for psychotic symptoms being a baseline marker of treatment response.

Description

Funder: University of Cambridge

Keywords

Adolescence, Depression severity, Psychotic symptoms, Unipolar depression, Adolescent, Adult, Cross-Sectional Studies, Depression, Depressive Disorder, Major, Hallucinations, Humans, Psychotic Disorders

Journal Title

Eur Child Adolesc Psychiatry

Conference Name

Journal ISSN

1018-8827
1435-165X

Volume Title

31

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (095844/Z/11/Z)
Department of Health (unknown)
NETSCC (None)