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dc.contributor.authorKehinde, Fiona
dc.contributor.authorBharmal, Aamena Valiji
dc.contributor.authorGoodyer, Ian M
dc.contributor.authorKelvin, Raphael
dc.contributor.authorDubicka, Bernadka
dc.contributor.authorMidgley, Nick
dc.contributor.authorFonagy, Peter
dc.contributor.authorJones, Peter B
dc.contributor.authorWilkinson, Paul
dc.contributor.authorIMPACT Consortium
dc.date.accessioned2022-05-27T16:08:07Z
dc.date.available2022-05-27T16:08:07Z
dc.date.issued2022-05
dc.date.submitted2020-07-02
dc.identifier.issn1018-8827
dc.identifier.others00787-020-01704-3
dc.identifier.other1704
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337547
dc.descriptionFunder: University of Cambridge
dc.description.abstractAdults with major depressive disorder (MDD) with psychotic features (delusions and/or hallucinations) have more severe symptoms and a worse prognosis. Subclinical psychotic symptoms are more common in adolescents than adults. However, the effects of psychotic symptoms on outcome of depressive symptoms have not been well studied in adolescents. Depressed adolescents aged 11-17 with and without psychotic symptoms were compared on depression severity scores at baseline and at 28- or 42-week follow-up in two large UK cohorts. Psychotic symptoms were weakly associated with more severe depression at baseline in both cohorts. At follow-up, baseline psychotic symptoms were only associated with depressive symptoms in one sample; in the other, the effect size was close to zero. This supports the DSM5 system of psychotic symptoms being a separate code to severity rather than the ICD10 system which only allows the diagnosis of psychotic depression with severe depression. There was no clear support for psychotic symptoms being a baseline marker of treatment response.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectOriginal Contribution
dc.subjectPsychotic symptoms
dc.subjectAdolescence
dc.subjectUnipolar depression
dc.subjectDepression severity
dc.titleCross-sectional and longitudinal associations between psychotic and depressive symptoms in depressed adolescents.
dc.typeArticle
dc.date.updated2022-05-27T16:08:06Z
prism.endingPage736
prism.issueIdentifier5
prism.publicationNameEur Child Adolesc Psychiatry
prism.startingPage729
prism.volume31
dc.identifier.doi10.17863/CAM.84956
dcterms.dateAccepted2020-12-07
rioxxterms.versionofrecord10.1007/s00787-020-01704-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWilkinson, Paul [0000-0003-3302-9662]
dc.identifier.eissn1435-165X
pubs.funder-project-idWellcome Trust (095844/Z/11/Z)
pubs.funder-project-idDepartment of Health (unknown)
pubs.funder-project-idNETSCC (None)
cam.issuedOnline2021-01-11


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