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dc.contributor.authorPaterson, Ian
dc.contributor.authorLam, Nelson
dc.date.accessioned2022-05-27T23:30:12Z
dc.date.available2022-05-27T23:30:12Z
dc.date.issued2022-05-25
dc.identifier.issn1099-0690
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337565
dc.description.abstractThe marine natural product hemicalide displays potent anticancer activity. While detailed NMR experiments established the planar carbon skeleton, its full configurational assignment proved enigmatic. This Review summarises ongoing synthetic efforts and NMR studies on hemicalide, which have succeeded in reducing the number of possible stereoisomers from more than one million to a more manageable eight structures, setting the stage for a focused total synthesis campaign.
dc.publisherWiley
dc.rightsAll Rights Reserved
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.titleDeep-sea discovery and detective work: towards solving the hemicalide structural enigma through computational NMR analysis and stereocontrolled synthesis.
dc.typeArticle
dc.publisher.departmentDepartment of Chemistry
dc.date.updated2022-05-25T09:43:30Z
prism.publicationNameEuropean Journal of Organic Chemistry
dc.identifier.doi10.17863/CAM.84974
dcterms.dateAccepted2022-05-24
rioxxterms.versionofrecord10.1002/ejoc.202200467
rioxxterms.versionAM
dc.contributor.orcidPaterson, Ian [0000-0002-8861-9136]
dc.contributor.orcidLam, Nelson [0000-0002-9307-0619]
rioxxterms.typeJournal Article/Review
cam.orpheus.successWed Jun 08 08:57:25 BST 2022 - Embargo updated*
cam.depositDate2022-05-25
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-05-25


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