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Deep-sea discovery and detective work: towards solving the hemicalide structural enigma through computational NMR analysis and stereocontrolled synthesis.

Accepted version
Peer-reviewed

Type

Article

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Abstract

The marine natural product hemicalide displays potent anticancer activity. While detailed NMR experiments established the planar carbon skeleton, its full configurational assignment proved enigmatic. This Review summarises ongoing synthetic efforts and NMR studies on hemicalide, which have succeeded in reducing the number of possible stereoisomers from more than one million to a more manageable eight structures, setting the stage for a focused total synthesis campaign.

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Keywords

Journal Title

European Journal of Organic Chemistry

Conference Name

Journal ISSN

1099-0690

Volume Title

Publisher

Wiley