Successful application of digital twins in the design process requires a tailored approach to identify high value information from the uncertain data. We propose a non-intrusive sensitivity metric toolbox that integrates black-box digital twins in the design and decision process under uncertainties. The toolbox captures the evolving nature of the key design performance indicators (KPI) and provide both KPI-free and KPI-based metrics. The KPI-free metrics, which are based on entropy and Fisher information but independent of design KPIs, is shown to give good indication of the most influential data for KPI-based metrics. This suggests a consistent identification of high value data throughout the design process.