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dc.contributor.authorJannasch, Franziska
dc.contributor.authorDietrich, Stefan
dc.contributor.authorBishop, Tom RP
dc.contributor.authorPearce, Matthew
dc.contributor.authorFanidi, Anouar
dc.contributor.authorO'Donoghue, Gráinne
dc.contributor.authorO'Gorman, Donal
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorVollenweider, Peter
dc.contributor.authorBes-Rastrollo, Maira
dc.contributor.authorByberg, Liisa
dc.contributor.authorWolk, Alicja
dc.contributor.authorHashemian, Maryam
dc.contributor.authorMalekzadeh, Reza
dc.contributor.authorPoustchi, Hossein
dc.contributor.authorLuft, Vivian C
dc.contributor.authorde Matos, Sheila M Alvim
dc.contributor.authorKim, Jihye
dc.contributor.authorKim, Mi Kyung
dc.contributor.authorKim, Yeonjung
dc.contributor.authorStern, Dalia
dc.contributor.authorLajous, Martin
dc.contributor.authorMagliano, Dianna J
dc.contributor.authorShaw, Jonathan E
dc.contributor.authorAkbaraly, Tasnime
dc.contributor.authorKivimaki, Mika
dc.contributor.authorMaskarinec, Gertraud
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorMartínez-González, Miguel Ángel
dc.contributor.authorSoedamah-Muthu, Sabita S
dc.contributor.authorEPIC-InterAct Consortium
dc.contributor.authorWareham, Nicholas
dc.contributor.authorForouhi, Nita G
dc.contributor.authorSchulze, Matthias B
dc.date.accessioned2022-06-01T23:30:41Z
dc.date.available2022-06-01T23:30:41Z
dc.date.issued2022-06-01
dc.identifier.issn1436-6207
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337676
dc.description.abstractPURPOSE: In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, findings remained study-specific, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world. METHODS: This federated meta-analysis of individual participant data was based on 25 prospective cohort studies from 5 continents including a total of 390,664 participants with a follow-up for T2D (3.8-25.0 years). After data harmonization across cohorts we evaluated 15 previously identified T2D-related DPs for association with incident T2D estimating pooled incidence rate ratios (IRR) and confidence intervals (CI) by Piecewise Poisson regression and random-effects meta-analysis. RESULTS: 29,386 participants developed T2D during follow-up. Five DPs, characterized by higher intake of red meat, processed meat, French fries and refined grains, were associated with higher incidence of T2D. The strongest association was observed for a DP comprising these food groups besides others (IRRpooled per 1 SD = 1.104, 95% CI 1.059-1.151). Although heterogeneity was present (I2 = 85%), IRR exceeded 1 in 18 of the 20 meta-analyzed studies. Original DPs associated with lower T2D risk were not confirmed. Instead, a healthy DP (HDP1) was associated with higher T2D risk (IRRpooled per 1 SD = 1.057, 95% CI 1.027-1.088). CONCLUSION: Our findings from various cohorts revealed positive associations for several DPs, characterized by higher intake of red meat, processed meat, French fries and refined grains, adding to the evidence-base that links DPs to higher T2D risk. However, no inverse DP-T2D associations were confirmed.
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAssociations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
dc.typeArticle
dc.publisher.departmentoffice of The School of Clinical Medicine
dc.date.updated2022-06-01T08:26:02Z
prism.publicationNameEur J Nutr
dc.identifier.doi10.17863/CAM.85082
dcterms.dateAccepted2022-05-09
rioxxterms.versionofrecord10.1007/s00394-022-02909-9
rioxxterms.versionVoR
dc.contributor.orcidJannasch, Franziska [0000-0003-3478-4758]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1436-6215
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission (37197)
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idEuropean Commission (602068)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (824989)
pubs.funder-project-idMRC (MC_UU_00006/3)
pubs.funder-project-idNational Institute for Health Research (IS-BRC-1215-20014)
pubs.funder-project-idCancer Research Uk (None)
cam.issuedOnline2022-06-01
cam.depositDate2022-06-01
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International