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dc.contributor.authorNguyen, Tuong L
dc.contributor.authorLi, Shuai
dc.contributor.authorDowty, James G
dc.contributor.authorDite, Gillian S
dc.contributor.authorYe, Zhoufeng
dc.contributor.authorNguyen-Dumont, Tu
dc.contributor.authorTrinh, Ho N
dc.contributor.authorEvans, Christopher F
dc.contributor.authorTan, Maxine
dc.contributor.authorSung, Joohon
dc.contributor.authorJenkins, Mark A
dc.contributor.authorGiles, Graham G
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorHopper, John L
dc.date.accessioned2022-06-07T08:10:23Z
dc.date.available2022-06-07T08:10:23Z
dc.date.issued2022-03-14
dc.identifier.issn2072-6694
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337735
dc.description.abstractCumulus, Cumulus-percent, Altocumulus, Cirrocumulus, and Cumulus-white are mammogram risk scores (MRSs) for breast cancer based on mammographic density defined in effect by different levels of pixel brightness and adjusted for age and body mass index. We measured these MRS from digitized film mammograms for 593 monozygotic (MZ) and 326 dizygotic (DZ) female twin pairs and 1592 of their sisters. We estimated the correlations in relatives (r) and the proportion of variance due to genetic factors (heritability) using the software FISHER and predicted the familial risk ratio (FRR) associated with each MRS. The ρ estimates ranged from: 0.41 to 0.60 (standard error [SE] 0.02) for MZ pairs, 0.16 to 0.26 (SE 0.05) for DZ pairs, and 0.19 to 0.29 (SE 0.02) for sister pairs (including pairs of a twin and her non-twin sister), respectively. Heritability estimates were 39% to 69% under the classic twin model and 36% to 56% when allowing for shared non-genetic factors specific to MZ pairs. The FRRs were 1.08 to 1.17. These MRSs are substantially familial, due mostly to genetic factors that explain one-quarter to one-half as much of the familial aggregation of breast cancer that is explained by the current best polygenic risk score.
dc.languageen
dc.publisherMDPI AG
dc.subjectbreast cancer
dc.subjectcirrocumulus
dc.subjectcumulus
dc.subjectfamilial risk ratio
dc.subjectheritability
dc.subjectmammogram risk score
dc.subjectmammographic density
dc.subjectOPERA
dc.titleFamilial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk.
dc.typeArticle
dc.date.updated2022-06-07T08:10:23Z
prism.issueIdentifier6
prism.publicationNameCancers (Basel)
prism.volume14
dc.identifier.doi10.17863/CAM.85144
dcterms.dateAccepted2022-03-08
rioxxterms.versionofrecord10.3390/cancers14061483
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLi, Shuai [0000-0002-8696-8594]
dc.contributor.orcidDite, Gillian S [0000-0002-2448-2548]
dc.contributor.orcidYe, Zhoufeng [0000-0002-0884-4246]
dc.contributor.orcidNguyen-Dumont, Tu [0000-0002-6217-0182]
dc.contributor.orcidSung, Joohon [0000-0001-9948-0160]
dc.identifier.eissn2072-6694
pubs.funder-project-idCancer Council Victoria (AF7305)
pubs.funder-project-idNational Institutes of Health (R01CA159868)
pubs.funder-project-idNational Health and Medical Research Council (APP809195)
pubs.funder-project-idVictorian Cancer Agency (ECRF19020)
cam.issuedOnline2022-03-14


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