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Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.

Published version
Peer-reviewed

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Authors

Lurette, Olivier 
Guedouari, Hala 
Morris, Jordan L 
Martín-Jiménez, Rebeca 
Robichaud, Julie-Pier 

Abstract

The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress. Understanding how these events are regulated is important to elucidate how mitochondrial dynamics control cell fate. Here, we show that the tyrosine kinase Src regulates mitochondrial morphology. Deletion of Src increased mitochondrial size and reduced cellular respiration independently of mitochondrial mass, mitochondrial membrane potential or ATP levels. Re-expression of Src targeted to the mitochondrial matrix, but not of Src targeted to the plasma membrane, rescued mitochondrial morphology in a kinase activity-dependent manner. These findings highlight a novel function for Src in the control of mitochondrial dynamics.

Description

Keywords

Original Article, Mitochondrial dynamics, Cellular respiration, Mitochondria-shaping protein, Oxidative phosphorylation

Journal Title

Cell Mol Life Sci

Conference Name

Journal ISSN

1420-682X
1420-9071

Volume Title

79

Publisher

Springer Science and Business Media LLC
Sponsorship
MRC (MC_UU_00015/7)
Medical Research Council (MC_UU_00015/7)