Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Morris, Jordan L
Cell Mol Life Sci
Springer Science and Business Media LLC
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Lurette, O., Guedouari, H., Morris, J. L., Martín-Jiménez, R., Robichaud, J., Hamel-Côté, G., Khan, M., et al. (2022). Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.. Cell Mol Life Sci, 79 (6) https://doi.org/10.1007/s00018-022-04325-y
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress. Understanding how these events are regulated is important to elucidate how mitochondrial dynamics control cell fate. Here, we show that the tyrosine kinase Src regulates mitochondrial morphology. Deletion of Src increased mitochondrial size and reduced cellular respiration independently of mitochondrial mass, mitochondrial membrane potential or ATP levels. Re-expression of Src targeted to the mitochondrial matrix, but not of Src targeted to the plasma membrane, rescued mitochondrial morphology in a kinase activity-dependent manner. These findings highlight a novel function for Src in the control of mitochondrial dynamics.
Original Article, Mitochondrial dynamics, Cellular respiration, Mitochondria-shaping protein, Oxidative phosphorylation
Medical Research Council (MC_UU_00015/7)
External DOI: https://doi.org/10.1007/s00018-022-04325-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/337751