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dc.contributor.authorFowden, Abigail
dc.contributor.authorVaughan, Owen R
dc.contributor.authorMurray, Andrew J
dc.contributor.authorForhead, Alison J
dc.date.accessioned2022-06-07T08:11:33Z
dc.date.available2022-06-07T08:11:33Z
dc.date.issued2022-05-30
dc.identifier.issn2072-6643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337758
dc.description.abstractGlucocorticoids have an important role in development of the metabolic phenotype in utero. They act as environmental and maturational signals in adapting feto-placental metabolism to maximize the chances of survival both before and at birth. They influence placental nutrient handling and fetal metabolic processes to support fetal growth, fuel storage and energy production with respect to nutrient availability. More specifically, they regulate the transport, utilization and production of a range of nutrients by the feto-placental tissues that enables greater metabolic flexibility in utero while minimizing any further drain on maternal resources during periods of stress. Near term, the natural rise in fetal glucocorticoid concentrations also stimulates key metabolic adaptations that prepare tissues for the new energy demanding functions after birth. Glucocorticoids, therefore, have a central role in the metabolic communication between the mother, placenta and fetus that optimizes offspring metabolic phenotype for survival to reproductive age. This review discusses the effects of maternal and fetal glucocorticoids on the supply and utilization of nutrients by the feto-placental tissues with particular emphasis on studies using quantitative methods to assess metabolism in rodents and sheep in vivo during late pregnancy. It considers the routes of glucocorticoid overexposure in utero, including experimental administration of synthetic glucocorticoids, and the mechanisms by which these hormones control feto-placental metabolism at the molecular, cellular and systems levels. It also briefly examines the consequences of intrauterine glucocorticoid overexposure for postnatal metabolic health and the generational inheritance of metabolic phenotype.
dc.languageen
dc.publisherMDPI AG
dc.subjectglucocorticoids
dc.subjectcortisol
dc.subjectplacenta
dc.subjectfetus
dc.subjectmetabolism
dc.subjectnutrients
dc.titleMetabolic Consequences of Glucocorticoid Exposure before Birth.
dc.typeArticle
dc.date.updated2022-06-07T08:11:32Z
prism.issueIdentifier11
prism.publicationNameNutrients
prism.volume14
dc.identifier.doi10.17863/CAM.85167
dcterms.dateAccepted2022-05-25
rioxxterms.versionofrecord10.3390/nu14112304
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFowden, Abigail [0000-0002-3384-4467]
dc.contributor.orcidVaughan, Owen R [0000-0001-7537-3264]
dc.identifier.eissn2072-6643
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/I011773/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P019048/1)
cam.issuedOnline2022-05-30


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