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dc.contributor.authorLi, Qingyang
dc.contributor.authorZhang, Lingli
dc.contributor.authorShan, Haidi
dc.contributor.authorYu, Juehua
dc.contributor.authorDai, Yuan
dc.contributor.authorHe, Hua
dc.contributor.authorLi, Wei-Guang
dc.contributor.authorLangley, Christelle
dc.contributor.authorSahakian, Barbara
dc.contributor.authorYao, Yin
dc.contributor.authorLuo, Qiang
dc.contributor.authorLi, Fei
dc.date.accessioned2022-06-07T08:13:02Z
dc.date.available2022-06-07T08:13:02Z
dc.date.issued2022-06-03
dc.date.submitted2021-08-20
dc.identifier.issn2158-3188
dc.identifier.others41398-022-01987-x
dc.identifier.other1987
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337786
dc.description.abstractBumetanide, a drug being studied in autism spectrum disorder (ASD) may act to restore gamma-aminobutyric acid (GABA) function, which may be modulated by the immune system. However, the interaction between bumetanide and the immune system remains unclear. Seventy-nine children with ASD were analysed from a longitudinal sample for a 3-month treatment of bumetanide. The covariation between symptom improvements and cytokine changes was calculated and validated by sparse canonical correlation analysis. Response patterns to bumetanide were revealed by clustering analysis. Five classifiers were used to test whether including the baseline information of cytokines could improve the prediction of the response patterns using an independent test sample. An immuno-behavioural covariation was identified between symptom improvements in the Childhood Autism Rating Scale (CARS) and the cytokine changes among interferon (IFN)-γ, monokine induced by gamma interferon and IFN-α2. Using this covariation, three groups with distinct response patterns to bumetanide were detected, including the best (21.5%, n = 17; Hedge's g of improvement in CARS = 2.16), the least (22.8%, n = 18; g = 1.02) and the medium (55.7%, n = 44; g = 1.42) responding groups. Including the cytokine levels significantly improved the prediction of the best responding group before treatment (the best area under the curve, AUC = 0.832) compared with the model without the cytokine levels (95% confidence interval of the improvement in AUC was [0.287, 0.319]). Cytokine measurements can help in identifying possible responders to bumetanide in ASD children, suggesting that immune responses may interact with the mechanism of action of bumetanide to enhance the GABA function in ASD.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/692/53/2423
dc.subject/692/699/476/1373
dc.subject/96/21
dc.subjectarticle
dc.titleThe immuno-behavioural covariation associated with the treatment response to bumetanide in young children with autism spectrum disorder.
dc.typeArticle
dc.date.updated2022-06-07T08:13:01Z
prism.issueIdentifier1
prism.publicationNameTransl Psychiatry
prism.volume12
dc.identifier.doi10.17863/CAM.85195
dcterms.dateAccepted2022-05-25
rioxxterms.versionofrecord10.1038/s41398-022-01987-x
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidLi, Qingyang [0000-0002-0474-3579]
dc.contributor.orcidYu, Juehua [0000-0002-1661-0503]
dc.contributor.orcidLi, Wei-Guang [0000-0002-3442-7518]
dc.contributor.orcidLangley, Christelle [0000-0001-5061-2820]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
dc.contributor.orcidYao, Yin [0000-0003-3053-8429]
dc.contributor.orcidLuo, Qiang [0000-0002-0426-6039]
dc.contributor.orcidLi, Fei [0000-0002-2455-4986]
dc.identifier.eissn2158-3188
pubs.funder-project-idNational Natural Science Foundation of China (National Science Foundation of China) (82125032, 81930095, 81761128035, 81873909 and 81761128011)
pubs.funder-project-idScience and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) (19410713500, 2018SHZDZX01, and 20ZR1404900)
cam.issuedOnline2022-06-03


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