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dc.contributor.authorWielscher, Matthias
dc.contributor.authorMandaviya, Pooja R
dc.contributor.authorKuehnel, Brigitte
dc.contributor.authorJoehanes, Roby
dc.contributor.authorMustafa, Rima
dc.contributor.authorRobinson, Oliver
dc.contributor.authorZhang, Yan
dc.contributor.authorBodinier, Barbara
dc.contributor.authorWalton, Esther
dc.contributor.authorMishra, Pashupati P
dc.contributor.authorSchlosser, Pascal
dc.contributor.authorWilson, Rory
dc.contributor.authorTsai, Pei-Chien
dc.contributor.authorPalaniswamy, Saranya
dc.contributor.authorMarioni, Riccardo E
dc.contributor.authorFiorito, Giovanni
dc.contributor.authorCugliari, Giovanni
dc.contributor.authorKarhunen, Ville
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorLoh, Marie
dc.contributor.authorBis, Joshua C
dc.contributor.authorLehne, Benjamin
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorDeary, Ian J
dc.contributor.authorChadeau-Hyam, Marc
dc.contributor.authorBrody, Jennifer A
dc.contributor.authorCardona, Alexia
dc.contributor.authorSelvin, Elizabeth
dc.contributor.authorSmith, Alicia K
dc.contributor.authorMiller, Andrew H
dc.contributor.authorTorres, Mylin A
dc.contributor.authorMarouli, Eirini
dc.contributor.authorGào, Xin
dc.contributor.authorvan Meurs, Joyce BJ
dc.contributor.authorGraf-Schindler, Johanna
dc.contributor.authorRathmann, Wolfgang
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorPeters, Annette
dc.contributor.authorWeninger, Wolfgang
dc.contributor.authorFarlik, Matthias
dc.contributor.authorZhang, Tao
dc.contributor.authorChen, Wei
dc.contributor.authorXia, Yujing
dc.contributor.authorTeumer, Alexander
dc.contributor.authorNauck, Matthias
dc.contributor.authorGrabe, Hans J
dc.contributor.authorDoerr, Macus
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorGuan, Weihua
dc.contributor.authorMilani, Lili
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorFisher, Krista
dc.contributor.authorWaite, Lindsay L
dc.contributor.authorKasela, Silva
dc.contributor.authorVineis, Paolo
dc.contributor.authorVerweij, Niek
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorIacoviello, Licia
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorPanico, Salvatore
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTumino, Rosario
dc.contributor.authorTzala, Evangelia
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorHurme, Mikko A
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorColicino, Elena
dc.contributor.authorBaccarelli, Andrea A
dc.contributor.authorKähönen, Mika
dc.contributor.authorHerzig, Karl-Heinz
dc.contributor.authorLi, Shengxu
dc.contributor.authorBIOS consortium
dc.contributor.authorConneely, Karen N
dc.contributor.authorKooner, Jaspal S
dc.contributor.authorKöttgen, Anna
dc.contributor.authorHeijmans, Bastiaan T
dc.contributor.authorDeloukas, Panos
dc.contributor.authorRelton, Caroline
dc.contributor.authorOng, Ken K
dc.contributor.authorBell, Jordana T
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorElliott, Paul
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBeekman, Marian
dc.contributor.authorLevy, Daniel
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorChambers, John C
dc.contributor.authorDehghan, Abbas
dc.contributor.authorJärvelin, Marjo-Riitta
dc.date.accessioned2022-06-07T08:13:36Z
dc.date.available2022-06-07T08:13:36Z
dc.date.issued2022-05-03
dc.identifier.issn2041-1723
dc.identifier.other35504910
dc.identifier.otherPMC9065016
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337796
dc.description.abstractWe performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101528555
dc.sourceessn: 2041-1723
dc.subjectHumans
dc.subjectInflammation
dc.subjectC-Reactive Protein
dc.subjectDNA Methylation
dc.subjectCpG Islands
dc.subjectNucleotide Motifs
dc.titleDNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
dc.typeArticle
dc.date.updated2022-06-07T08:13:35Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
dc.identifier.doi10.17863/CAM.85205
dcterms.dateAccepted2022-03-31
rioxxterms.versionofrecord10.1038/s41467-022-29792-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWielscher, Matthias [0000-0003-4138-1383]
dc.contributor.orcidMustafa, Rima [0000-0003-2623-5337]
dc.contributor.orcidRobinson, Oliver [0000-0002-4735-0468]
dc.contributor.orcidBodinier, Barbara [0000-0002-0781-3624]
dc.contributor.orcidWalton, Esther [0000-0002-0935-2200]
dc.contributor.orcidSchlosser, Pascal [0000-0002-8460-0462]
dc.contributor.orcidWilson, Rory [0000-0001-6135-3764]
dc.contributor.orcidPalaniswamy, Saranya [0000-0003-4145-540X]
dc.contributor.orcidKarhunen, Ville [0000-0001-6064-1588]
dc.contributor.orcidGhanbari, Mohsen [0000-0002-9476-7143]
dc.contributor.orcidPsaty, Bruce M [0000-0002-7278-2190]
dc.contributor.orcidLoh, Marie [0000-0003-3626-8466]
dc.contributor.orcidBis, Joshua C [0000-0002-3409-1110]
dc.contributor.orcidChadeau-Hyam, Marc [0000-0001-8341-5436]
dc.contributor.orcidBrody, Jennifer A [0000-0001-8509-148X]
dc.contributor.orcidCardona, Alexia [0000-0002-7877-5565]
dc.contributor.orcidSmith, Alicia K [0000-0002-8537-5156]
dc.contributor.orcidMiller, Andrew H [0000-0001-8260-7997]
dc.contributor.orcidMarouli, Eirini [0000-0001-6179-1609]
dc.contributor.orcidGào, Xin [0000-0003-0108-6961]
dc.contributor.orcidKoenig, Wolfgang [0000-0002-2064-9603]
dc.contributor.orcidPeters, Annette [0000-0001-6645-0985]
dc.contributor.orcidFarlik, Matthias [0000-0003-0698-2992]
dc.contributor.orcidChen, Wei [0000-0003-1566-7943]
dc.contributor.orcidXia, Yujing [0000-0003-0850-5591]
dc.contributor.orcidTeumer, Alexander [0000-0002-8309-094X]
dc.contributor.orcidNauck, Matthias [0000-0002-6678-7964]
dc.contributor.orcidDoerr, Macus [0000-0001-7471-475X]
dc.contributor.orcidLehtimäki, Terho [0000-0002-2555-4427]
dc.contributor.orcidMilani, Lili [0000-0002-5323-3102]
dc.contributor.orcidFisher, Krista [0000-0002-3521-0599]
dc.contributor.orcidvan der Harst, Pim [0000-0002-2713-686X]
dc.contributor.orcidKrogh, Vittorio [0000-0003-0122-8624]
dc.contributor.orcidHerzig, Karl-Heinz [0000-0003-4460-2604]
dc.contributor.orcidLi, Shengxu [0000-0001-9210-7283]
dc.contributor.orcidKöttgen, Anna [0000-0002-4671-3714]
dc.contributor.orcidHeijmans, Bastiaan T [0000-0001-5918-0534]
dc.contributor.orcidDeloukas, Panos [0000-0001-9251-070X]
dc.contributor.orcidOng, Ken K [0000-0003-4689-7530]
dc.contributor.orcidBell, Jordana T [0000-0002-3858-5986]
dc.contributor.orcidElliott, Paul [0000-0002-7511-5684]
dc.contributor.orcidBrenner, Hermann [0000-0002-6129-1572]
dc.contributor.orcidBeekman, Marian [0000-0003-0585-6206]
dc.contributor.orcidWaldenberger, Melanie [0000-0003-0583-5093]
dc.contributor.orcidChambers, John C [0000-0003-0209-4541]
dc.contributor.orcidDehghan, Abbas [0000-0001-6403-016X]
dc.contributor.orcidJärvelin, Marjo-Riitta [0000-0002-2149-0630]
dc.identifier.eissn2041-1723
pubs.funder-project-idMRC (MC_UU_00006/2)
cam.issuedOnline2022-05-03


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International