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dc.contributor.authorZhang, Yang
dc.contributor.authorGarcia-Ibanez, Laura
dc.contributor.authorUlbricht, Carolin
dc.contributor.authorLok, Laurence SC
dc.contributor.authorPike, Jeremy A
dc.contributor.authorMueller-Winkler, Jennifer
dc.contributor.authorDennison, Thomas W
dc.contributor.authorFerdinand, John R
dc.contributor.authorBurnett, Cameron JM
dc.contributor.authorYam-Puc, Juan C
dc.contributor.authorZhang, Lingling
dc.contributor.authorAlfaro, Raul Maqueda
dc.contributor.authorTakahama, Yousuke
dc.contributor.authorOhigashi, Izumi
dc.contributor.authorBrown, Geoffrey
dc.contributor.authorKurosaki, Tomohiro
dc.contributor.authorTybulewicz, Victor LJ
dc.contributor.authorRot, Antal
dc.contributor.authorHauser, Anja E
dc.contributor.authorClatworthy, Menna R
dc.contributor.authorToellner, Kai-Michael
dc.date.accessioned2022-06-07T08:13:58Z
dc.date.available2022-06-07T08:13:58Z
dc.date.issued2022-05-05
dc.identifier.issn2041-1723
dc.identifier.other35513371
dc.identifier.otherPMC9072412
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337804
dc.description.abstractInfection or vaccination leads to the development of germinal centers (GC) where B cells evolve high affinity antigen receptors, eventually producing antibody-forming plasma cells or memory B cells. Here we follow the migratory pathways of B cells emerging from germinal centers (BEM) and find that many BEM cells migrate into the lymph node subcapsular sinus (SCS) guided by sphingosine-1-phosphate (S1P). From the SCS, BEM cells may exit the lymph node to enter distant tissues, while some BEM cells interact with and take up antigen from SCS macrophages, followed by CCL21-guided return towards the GC. Disruption of local CCL21 gradients inhibits the recycling of BEM cells and results in less efficient adaption to antigenic variation. Our findings thus suggest that the recycling of antigen variant-specific BEM cells and transport of antigen back to GC may support affinity maturation to antigenic drift.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101528555
dc.sourceessn: 2041-1723
dc.subjectGerminal Center
dc.subjectLymph Nodes
dc.subjectB-Lymphocytes
dc.subjectAntigenic Drift and Shift
dc.subjectMemory B Cells
dc.titleRecycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift.
dc.typeArticle
dc.date.updated2022-06-07T08:13:58Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume13
dc.identifier.doi10.17863/CAM.85213
dcterms.dateAccepted2022-03-31
rioxxterms.versionofrecord10.1038/s41467-022-29978-y
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidUlbricht, Carolin [0000-0003-2983-6242]
dc.contributor.orcidLok, Laurence SC [0000-0002-9364-4213]
dc.contributor.orcidBurnett, Cameron JM [0000-0001-6367-9004]
dc.contributor.orcidYam-Puc, Juan C [0000-0003-4395-8844]
dc.contributor.orcidZhang, Lingling [0000-0001-7423-3761]
dc.contributor.orcidAlfaro, Raul Maqueda [0000-0003-3538-1176]
dc.contributor.orcidTakahama, Yousuke [0000-0002-4992-9174]
dc.contributor.orcidBrown, Geoffrey [0000-0003-0821-0275]
dc.contributor.orcidKurosaki, Tomohiro [0000-0002-6352-304X]
dc.contributor.orcidTybulewicz, Victor LJ [0000-0003-2439-0798]
dc.contributor.orcidToellner, Kai-Michael [0000-0001-8404-645X]
dc.identifier.eissn2041-1723
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/S003800/1, BB/M025292/1)
pubs.funder-project-idDeutsche Forschungsgemeinschaft (German Research Foundation) (C01, HA5354/10-1, TRR130, TP17)
pubs.funder-project-idMedical Research Council (MR/N024907/1, MR/P001874/1)
pubs.funder-project-idWellcome Trust (104384/Z/14/Z, FC001194)
pubs.funder-project-idVersus Arthritis (21777)
pubs.funder-project-idEuropean Commission (EC) (DECIDE)
pubs.funder-project-idDH | National Institute for Health Research (NIHR) (RP-2017-08-ST2-002)
pubs.funder-project-idNational Institute for Health Research (NIHR) (RP-2017-08-ST2-002)
cam.issuedOnline2022-05-05


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International