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dc.contributor.authorSiciliano, Mattia
dc.contributor.authorKluger, Benzi
dc.contributor.authorDe Micco, Rosa
dc.contributor.authorChiorri, Carlo
dc.contributor.authorSant'Elia, Valeria
dc.contributor.authorSilvestro, Marcello
dc.contributor.authorGiordano, Alfonso
dc.contributor.authorTedeschi, Gioacchino
dc.contributor.authorPassamonti, Luca
dc.contributor.authorTrojano, Luigi
dc.contributor.authorTessitore, Alessandro
dc.date.accessioned2022-06-07T08:16:27Z
dc.date.available2022-06-07T08:16:27Z
dc.date.issued2022-09
dc.date.submitted2022-03-21
dc.identifier.issn1351-5101
dc.identifier.otherene15411
dc.identifier.otherejon-22-0697.r1
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337830
dc.description.abstractBACKGROUND AND PURPOSE: Although disabling fatigue is common in Parkinson disease (PD), available consensus-based diagnostic criteria have not yet been empirically validated. The aim of this study was to evaluate the clinimetric properties of the criteria. METHODS: A sample of outpatients with PD was evaluated for demographic, clinical, behavioral, and cognitive features. Fatigue was diagnosed according to the new diagnostic criteria and was rated by means of the Parkinson Fatigue Scale (PFS) and Fatigue Severity Scale (FSS). Acceptability, concurrent and discriminant validity, and interrater reliability were evaluated with binary logistic regression analyses and Cohen kappa (κ). RESULTS: Of 241 included patients, 17 (7.1%) met the diagnostic criteria for PD-related fatigue. Eight of nine symptoms described in Section A of the diagnostic criteria occurred in >50% of patients with fatigue. Acceptability (missing data = 0.8%) of the criteria was good, as was their concurrent validity with the PFS (odds ratio = 3.65) and FSS (odds ratio = 3.63). The discriminant validity of fatigue criteria with other PD-related behavioral and cognitive features was good (odds ratio < 1.68). The interrater reliability was excellent (κ = 0.92). CONCLUSIONS: This is the first study to test the clinimetric properties of case definition diagnostic criteria for PD-related fatigue. Our results suggest that current diagnostic criteria may be useful in both clinical practice and research. Future longitudinal studies should examine their long-term stability.
dc.languageen
dc.publisherWiley
dc.subjectORIGINAL ARTICLE
dc.subjectORIGINAL ARTICLES
dc.subjectfatigability
dc.subjectfatigue
dc.subjectnonmotor symptoms
dc.subjectParkinson disease
dc.subjectvalidation
dc.titleValidation of new diagnostic criteria for fatigue in patients with Parkinson disease.
dc.typeArticle
dc.date.updated2022-06-07T08:16:27Z
prism.publicationNameEur J Neurol
dc.identifier.doi10.17863/CAM.85239
dcterms.dateAccepted2022-05-12
rioxxterms.versionofrecord10.1111/ene.15411
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.contributor.orcidSiciliano, Mattia [0000-0001-5246-2109]
dc.contributor.orcidDe Micco, Rosa [0000-0002-6397-8888]
dc.contributor.orcidTrojano, Luigi [0000-0002-0328-9642]
dc.identifier.eissn1468-1331
cam.issuedOnline2022-06-06


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