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dc.contributor.authorFolayan, Morenike Oluwatoyin
dc.contributor.authorAliyu, Sani
dc.contributor.authorOginni, Ayodeji
dc.contributor.authorEzechi, Oliver
dc.contributor.authorKolawole, Grace
dc.contributor.authorEzeama, Nkiru
dc.contributor.authorDadem, Nancin
dc.contributor.authorAnenih, James
dc.contributor.authorAlagi, Matthias
dc.contributor.authorEkanem, Etim
dc.contributor.authorAfiadigwe, Evaristus
dc.contributor.authorAguolu, Rose
dc.contributor.authorOyebode, Tinuade
dc.contributor.authorBabalola-Jacobs, Alero
dc.contributor.authorSagay, Atiene
dc.contributor.authorNweneka, Chidi
dc.contributor.authorKamofu, Hadiza
dc.contributor.authorIdoko, John
dc.date.accessioned2022-06-07T08:16:46Z
dc.date.available2022-06-07T08:16:46Z
dc.date.issued2022
dc.identifier.issn1932-6203
dc.identifier.other35511948
dc.identifier.otherPMC9070899
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337838
dc.description.abstractOBJECTIVES: To evaluate the effectiveness of three models for pre-exposure prophylaxis (PrEP) service delivery to HIV-1 serodiscordant couples in Nigeria. METHODS: 297 heterosexual HIV-1 serodiscordant couples were recruited into three PrEP delivery models and followed up for 18 months. The models were i) Outpatient clinic model providing PreP in routine outpatient care; ii) Antiretroviral therapy (ART) clinic model providing PrEP in ART clinics; and iii) Decentralized care model providing PrEP through primary and secondary care centres linked to a tertiary care centre. The primary effectiveness endpoint was incident HIV-1 infection. The HIV incidence before and after the study was compared and the incidence rate ratio computed for each model. Survival analysis was conducted, Cox regression analysis was used to compare the factors that influenced couple retention in each of the models. Kaplan-Meier survival analysis was used to estimate the median retention time (in months) of the study participants in each of the study models, and log-rank test for equality of survival functions was conducted to test for significant differences among the three models. RESULTS: There was no significant difference (p>0.05) in the couple retention rates among the three models. At months 3, 6 and 9, adherence of the HIV-1-infected partners to ART was highest in the decentralized model, whereas at months 9 and 12, the outpatient model had the highest proportion of HIV-1- uninfected partners adhering to PrEP (p<0.001). The HIV incidence per 100 person-years was zero in the general outpatient clinic and ART clinic models and 1.6 (95% CI: 0.04-9.1) in the decentralized clinic model. The difference in the observed and expected incidence rate was 4.3 (95% CI: 0.44-39.57) for the decentralized clinic model. CONCLUSION: Although incidence of HIV seroconversion was highest in the decentralized clinic model, this difference may be due to the higher sexual risk behavior among study participants in the decentralized model rather than the type of service delivery. The study findings imply that any of the models can effectively deliver PrEP services.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101285081
dc.sourceessn: 1932-6203
dc.subjectHumans
dc.subjectHIV-1
dc.subjectHIV Infections
dc.subjectHIV Seropositivity
dc.subjectAnti-HIV Agents
dc.subjectSexual Partners
dc.subjectNigeria
dc.subjectPre-Exposure Prophylaxis
dc.titleEffectiveness of three delivery models for promoting access to pre-exposure prophylaxis in HIV-1 serodiscordant couples in Nigeria.
dc.typeArticle
dc.date.updated2022-06-07T08:16:45Z
prism.issueIdentifier5
prism.publicationNamePLoS One
prism.volume17
dc.identifier.doi10.17863/CAM.85247
dcterms.dateAccepted2022-04-19
rioxxterms.versionofrecord10.1371/journal.pone.0268011
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidFolayan, Morenike Oluwatoyin [0000-0002-9008-7730]
dc.contributor.orcidNweneka, Chidi [0000-0002-7278-2035]
dc.identifier.eissn1932-6203
cam.issuedOnline2022-05-05


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International