Cost-effectiveness of vitamin D₃ supplementation in older adults with vitamin D deficiency in Ireland

Abstract

<jats:sec><jats:title>Background</jats:title><jats:p>This study investigated the cost-effectiveness of vitamin D<jats:sub>3</jats:sub> supplementation in older adults in Ireland, with year-round vitamin D deficiency (serum 25-hydroxyvitamin D concentration &lt;30 nmol/L) (13% of Irish adults), from the perspective of the Health Service Executive.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Three age groups were investigated: (1) ≥50 years, (2) ≥60 years and (3) ≥70 years. Based on the clinical literature, vitamin D<jats:sub>3</jats:sub> supplementation may: (1) decrease all-cause mortality by 7% and (2) reduce hip fractures by 16% and non-hip fractures by 20%. A discount rate of 4% was applied to life years and quality-adjusted life years (QALYs) gained, and healthcare costs. The annual healthcare costs per patient used in the model are based on the average annual health resource use over the 5-year time horizon of the model.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The cost/QALY estimates in all three age groups are below the usually acceptable cost-effectiveness threshold of €20 000/QALY. The most cost-effective and least costly intervention was in adults ≥70 years. For this age group, the average annual costs and outcomes would be approximately €5.6 million, 1044 QALYs gained, with a cost/QALY of approximately €5400. The results are most sensitive to the mortality risk reduction following vitamin D<jats:sub>3</jats:sub> supplementation.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The cost-effectiveness of vitamin D<jats:sub>3</jats:sub> supplementation is most robust in adults ≥70 years. Clinical uncertainty in the magnitude of the benefits of vitamin D<jats:sub>3</jats:sub> supplementation could be further addressed by means of: (1) performing a clinical research study or (2) conducting a pilot/regional study, prior to reaching a decision to invest in a nationwide programme.</jats:p></jats:sec>