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dc.contributor.authorLacey, Laurence Francis
dc.contributor.authorArmstrong, David J
dc.contributor.authorRoyle, Emily
dc.contributor.authorMagee, Pamela
dc.contributor.authorPourshahidi, L Kirsty
dc.contributor.authorRay, Sumantra
dc.contributor.authorStrain, JJ
dc.contributor.authorMcSorley, Emeir
dc.date.accessioned2022-06-07T08:17:32Z
dc.date.available2022-06-07T08:17:32Z
dc.date.issued2022
dc.date.submitted2021-09-30
dc.identifier.citationBMJ Nutrition, Prevention & Health, page e000382
dc.identifier.issn2516-5542
dc.identifier.otherbmjnph-2021-000382
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337856
dc.description.abstractBackground: This study investigated the cost-effectiveness of vitamin D3 supplementation in older adults in Ireland, with year-round vitamin D deficiency (serum 25-hydroxyvitamin D concentration <30 nmol/L) (13% of Irish adults), from the perspective of the Health Service Executive. Methods: Three age groups were investigated: (1) ≥50 years, (2) ≥60 years and (3) ≥70 years. Based on the clinical literature, vitamin D3 supplementation may: (1) decrease all-cause mortality by 7% and (2) reduce hip fractures by 16% and non-hip fractures by 20%. A discount rate of 4% was applied to life years and quality-adjusted life years (QALYs) gained, and healthcare costs. The annual healthcare costs per patient used in the model are based on the average annual health resource use over the 5-year time horizon of the model. Results: The cost/QALY estimates in all three age groups are below the usually acceptable cost-effectiveness threshold of €20 000/QALY. The most cost-effective and least costly intervention was in adults ≥70 years. For this age group, the average annual costs and outcomes would be approximately €5.6 million, 1044 QALYs gained, with a cost/QALY of approximately €5400. The results are most sensitive to the mortality risk reduction following vitamin D3 supplementation. Conclusion: The cost-effectiveness of vitamin D3 supplementation is most robust in adults ≥70 years. Clinical uncertainty in the magnitude of the benefits of vitamin D3 supplementation could be further addressed by means of: (1) performing a clinical research study or (2) conducting a pilot/regional study, prior to reaching a decision to invest in a nationwide programme.
dc.languageen
dc.publisherBMJ
dc.subjectOriginal research
dc.subject1506
dc.subjectnutrient deficiencies
dc.subjectnutrition assessment
dc.subjectnutritional treatment
dc.titleCost-effectiveness of vitamin D3 supplementation in older adults with vitamin D deficiency in Ireland.
dc.typeArticle
dc.date.updated2022-06-07T08:17:32Z
prism.publicationNameBMJ Nutr Prev Health
dc.identifier.doi10.17863/CAM.85265
dcterms.dateAccepted2022-04-18
rioxxterms.versionofrecord10.1136/bmjnph-2021-000382
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2022-05-26
dc.contributor.orcidLacey, Laurence Francis [0000-0002-1393-8773]
dc.identifier.eissn2516-5542
cam.issuedOnline2022-05-26
rioxxterms.freetoread.startdate2022-05-26
rioxxterms.freetoread.startdate2022-05-26


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