The zip files contain the following data:

In the InSilico folder,

1. RawLnet: Raw binary mask of an examplar L-System
2. OpticalSimLnet: Intermediate L-Net post forward optical simulation
3. AcousticSimLnet: Reconstructed L-Net post acoustic simulation
4. FinalDenoisedLnet: Final denoised L-Net used for analysis
5. VesselnessFilteredLNet: (optional) Vesselness filtered final L-Net
6. SegmentedLNet: Final segmented L-Net using the four proposed methods (auto-thresholding, auto-thresholding + vesselness filtering, random forest, random forest + vesselness filtering)

In the Phantom folder,

1. RawPhantom: Raw reconstructed string image exported from the RSOM
2. FinalDenoisedPhantom: Final denoised string image used for analysis
3. VesselnessFilteredPhantom: (optional) Vesselness filtered string image
4. SegmentedPhantom: Final segmented string image using the four proposed methods (auto-thresholding, auto-thresholding + vesselness filtering, random forest, random forest + vesselness filtering)

In the InVivo folder,

1. RawRSOM: Raw reconstructed tumour image exported from the RSOM
2. FinalDenoisedRSOM: Final denoised tumour image used for analysis
3. VesselnessFilteredRSOM: (optional) Vesselness filtered tumour image
4. SegmentedRSOM: Final segmented tumour image using the four proposed methods (auto-thresholding, auto-thresholding + vesselness filtering, random forest, random forest + vesselness filtering)