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dc.contributor.authorMerchant, Monique
dc.contributor.authorMata, Carlos P
dc.contributor.authorLiu, Yangci
dc.contributor.authorZhai, Haoming
dc.contributor.authorProtasio, Anna
dc.contributor.authorModis, Yorgo
dc.description.abstractEndogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm Ancylostoma ceylanicum, with an envelope protein genetically related to GN-GC glycoproteins from the family Phenuiviridae. A cryo-EM structure of Atlas GC reveals a class II viral membrane fusion protein fold not previously seen in retroviruses. Atlas GC has the structural hallmarks of an active fusogen. Atlas GC trimers insert into membranes with endosomal lipid compositions and low pH. When expressed on the plasma membrane, Atlas GC has cell-cell fusion activity. With its preserved biological activities, Atlas GC has the potential to acquire a cellular function. Our work reveals structural plasticity in reverse-transcribing RNA viruses.
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.rightsAttribution 4.0 International
dc.titleA bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.
dc.publisher.departmentDepartment of Medicine
prism.publicationNameSci Adv
dc.contributor.orcidMerchant, Monique [0000-0002-6783-7193]
dc.contributor.orcidMata, Carlos P [0000-0003-3381-7431]
dc.contributor.orcidLiu, Yangci [0000-0001-8843-3529]
dc.contributor.orcidProtasio, Anna [0000-0003-1723-800X]
dc.contributor.orcidModis, Yorgo [0000-0002-6084-0429]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (101908/Z/13/Z)
pubs.funder-project-idNational Institute of General Medical Sciences (R01GM102869)
pubs.funder-project-idWellcome Trust (217191/Z/19/Z)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement

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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International