Show simple item record

dc.contributor.authorHunter, Michael
dc.contributor.authorFusco, Diana
dc.date.accessioned2022-06-10T01:05:54Z
dc.date.available2022-06-10T01:05:54Z
dc.date.issued2022-05
dc.identifier.issn1553-734X
dc.identifier.other35536864
dc.identifier.otherPMC9122224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337973
dc.description.abstractViral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but how this strategic choice impacts the fate of mutations in the viral population remains unclear. Using stochastic simulations, we find that genetic drift is suppressed when superinfection occurs, thus facilitating the fixation of beneficial mutations and the removal of deleterious ones. Interestingly, we also find that the competitive (dis)advantage associated with variations in life history parameters is not necessarily captured by the viral growth rate for either infection strategy. Putting these together, we then show that a mutant with superinfection exclusion will easily overtake a superinfecting population even if the latter has a much higher growth rate. Our findings suggest that while superinfection exclusion can negatively impact the long-term adaptation of a viral population, in the short-term it is ultimately a winning strategy.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101238922
dc.sourceessn: 1553-7358
dc.subjectHumans
dc.subjectSuperinfection
dc.titleSuperinfection exclusion: A viral strategy with short-term benefits and long-term drawbacks.
dc.typeArticle
dc.date.updated2022-06-10T01:05:53Z
prism.issueIdentifier5
prism.publicationNamePLoS Comput Biol
prism.volume18
dc.identifier.doi10.17863/CAM.85379
dcterms.dateAccepted2022-04-20
rioxxterms.versionofrecord10.1371/journal.pcbi.1010125
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidHunter, Michael [0000-0001-5439-2896]
dc.contributor.orcidFusco, Diana [0000-0002-1505-7160]
dc.identifier.eissn1553-7358
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/P020259/1)
cam.issuedOnline2022-05-10


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International