Age-Related Adaptive Immune Changes in Parkinson's Disease.
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Publication Date
2022Journal Title
J Parkinsons Dis
ISSN
1877-7171
Publisher
IOS Press
Pages
1-12
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Kouli, A., & Williams-Gray, C. H. (2022). Age-Related Adaptive Immune Changes in Parkinson's Disease.. J Parkinsons Dis, 1-12. https://doi.org/10.3233/JPD-223228
Abstract
Ageing is a major risk factor for most neurodegenerative diseases, including Parkinson's disease (PD). Progressive age-related dysregulation of the immune system is termed immunosenescence and is responsible for the weakened response to novel antigens, increased susceptibility to infections and reduced effectiveness of vaccines seen in the elderly. Immune activation, both within the brain and periphery, is heavily implicated in PD but the role of immunosenescence has not been fully explored. Studies to date provide some evidence for an attenuation in immunosenescence in PD, particularly a reduction in senescent CD8 T lymphocytes in PD cases compared to similarly aged controls. Here, we discuss recent evidence of age-related immune abnormalities in PD with a focus on T cell senescence and explore their potential role in disease pathogenesis and development.
Keywords
Parkinson’s disease, T lymphocytes, ageing, immunosenescence, Aged, Aging, Cellular Senescence, Humans, Immunosenescence, Parkinson Disease, T-Lymphocytes
Sponsorship
Medical Research Council (MR/R007446/1)
National Institute for Health Research (IS-BRC-1215-20014)
Identifiers
External DOI: https://doi.org/10.3233/JPD-223228
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338011
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