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Age-Related Adaptive Immune Changes in Parkinson's Disease.

Accepted version
Peer-reviewed

Type

Article

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Authors

Williams-Gray, Caroline H 

Abstract

Ageing is a major risk factor for most neurodegenerative diseases, including Parkinson's disease (PD). Progressive age-related dysregulation of the immune system is termed immunosenescence and is responsible for the weakened response to novel antigens, increased susceptibility to infections and reduced effectiveness of vaccines seen in the elderly. Immune activation, both within the brain and periphery, is heavily implicated in PD but the role of immunosenescence has not been fully explored. Studies to date provide some evidence for an attenuation in immunosenescence in PD, particularly a reduction in senescent CD8 T lymphocytes in PD cases compared to similarly aged controls. Here, we discuss recent evidence of age-related immune abnormalities in PD with a focus on T cell senescence and explore their potential role in disease pathogenesis and development.

Description

Keywords

Parkinson’s disease, T lymphocytes, ageing, immunosenescence, Aged, Aging, Cellular Senescence, Humans, Immunosenescence, Parkinson Disease, T-Lymphocytes

Journal Title

J Parkinsons Dis

Conference Name

Journal ISSN

1877-7171
1877-718X

Volume Title

Publisher

IOS Press
Sponsorship
Medical Research Council (MR/R007446/1)
National Institute for Health and Care Research (IS-BRC-1215-20014)