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dc.contributor.authorKouli, Antonina
dc.contributor.authorWilliams-Gray, Caroline
dc.date.accessioned2022-06-10T23:30:50Z
dc.date.available2022-06-10T23:30:50Z
dc.date.issued2022-06-01
dc.identifier.issn1877-7171
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338011
dc.description.abstractAgeing is a major risk factor for most neurodegenerative diseases, including Parkinson's disease (PD). Progressive age-related dysregulation of the immune system is termed immunosenescence and is responsible for the weakened response to novel antigens, increased susceptibility to infections and reduced effectiveness of vaccines seen in the elderly. Immune activation, both within the brain and periphery, is heavily implicated in PD but the role of immunosenescence has not been fully explored. Studies to date provide some evidence for an attenuation in immunosenescence in PD, particularly a reduction in senescent CD8 T lymphocytes in PD cases compared to similarly aged controls. Here, we discuss recent evidence of age-related immune abnormalities in PD with a focus on T cell senescence and explore their potential role in disease pathogenesis and development.
dc.publisherIOS Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAge-Related Adaptive Immune Changes in Parkinson's Disease.
dc.typeArticle
dc.publisher.departmentJohn Van Geest Centre For Brain Repair
dc.publisher.departmentDepartment of Clinical Neurosciences
dc.date.updated2022-06-09T15:29:36Z
prism.endingPage12
prism.publicationDate2022
prism.publicationNameJ Parkinsons Dis
prism.startingPage1
dc.identifier.doi10.17863/CAM.85416
dcterms.dateAccepted2022-05-04
rioxxterms.versionofrecord10.3233/JPD-223228
rioxxterms.versionAM
dc.contributor.orcidKouli, Antonina [0000-0001-6553-6154]
dc.contributor.orcidWilliams-Gray, Caroline [0000-0002-2648-9743]
dc.identifier.eissn1877-718X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R007446/1)
cam.issuedOnline2022-06-01
cam.orpheus.success2022-06-10 - Embargo set during processing via Fast-track
cam.depositDate2022-06-09
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2022-06-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International