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dc.contributor.authorWu, Olivia
dc.contributor.authorMorris, Stephen
dc.contributor.authorLarsen, Torben Bjerregaard
dc.contributor.authorSkjøth, Flemming
dc.contributor.authorEvans, Alex
dc.contributor.authorBowrin, Kevin
dc.contributor.authorWojciechowski, Piotr
dc.contributor.authorMargas, Wojciech
dc.contributor.authorHuelsebeck, Maria
dc.date.accessioned2022-06-12T08:00:15Z
dc.date.available2022-06-12T08:00:15Z
dc.date.issued2022
dc.identifier.citationOlivia Wu, Stephen Morris, Torben Bjerregaard Larsen, et al., “Effectiveness and Safety of Nonvitamin K Oral Anticoagulants Rivaroxaban and Apixaban in Patients with Venous Thromboembolism: A Meta-Analysis of Real-World Studies,” Cardiovascular Therapeutics, vol. 2022, Article ID 2756682, 11 pages, 2022. doi:10.1155/2022/2756682
dc.identifier.issn1755-5914
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338027
dc.description.abstractBackground: Rivaroxaban and apixaban are the most widely used nonvitamin K oral anticoagulants (NOACs) in patients with venous thromboembolism (VTE). This meta-analysis evaluates the effectiveness and safety of both NOACs versus standard of care (SoC) in real-world practice. Methods: Real-world evidence (RWE) studies were identified through a systematic literature review conducted between January 2012 and July 2020, using Embase, MEDLINE, and the websites of cardiological, hematological, and oncological associations. Eligible RWE studies recruited adult patients with deep vein thrombosis and/or pulmonary embolism and presented a comparison between rivaroxaban and apixaban versus SoC, consisting either of vitamin K antagonists, heparins, or combinations thereof. Hazard ratios (HRs) for the comparison between NOACs and SoC were extracted from the relevant studies or estimated based on the reported binary data. The between-treatment contrasts were reported as HRs with associated 95% confidence intervals. Results: A total of 65 RWE studies were identified and considered relevant for the meta-analysis. Compared with SoC, both rivaroxaban and apixaban were associated with reduced risks of recurrent VTE and a lower rate of major bleeding events. Patients treated with rivaroxaban were at a lower risk of all-cause death compared with those receiving SoC (HR = 0.56 [0.39-0.80]), while evidence for apixaban from the identified studies was insufficient to demonstrate a statistically significant change in mortality (HR = 0.66 [0.30-1.47]). Conclusion: This analysis indicates that in real-world practice, rivaroxaban and apixaban are associated with a lower risk of recurrent VTE and major bleeding events compared with SoC. Survival benefit in patients treated with rivaroxaban was also observed.
dc.publisherHindawi Limited
dc.titleEffectiveness and Safety of Nonvitamin K Oral Anticoagulants Rivaroxaban and Apixaban in Patients with Venous Thromboembolism: A Meta-Analysis of Real-World Studies.
dc.typeJournal Article
dc.date.updated2022-06-12T08:00:13Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2022 Olivia Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
prism.publicationNameCardiovasc Ther
dc.identifier.doi10.17863/CAM.85432
dcterms.dateAccepted2022-05-20
rioxxterms.versionofrecord10.1155/2022/2756682
dc.contributor.orcidWu, Olivia [0000-0002-0570-6016]
dc.contributor.orcidMorris, Stephen [0000-0002-5828-3563]
dc.contributor.orcidLarsen, Torben Bjerregaard [0000-0002-8485-8674]
dc.contributor.orcidSkjøth, Flemming [0000-0003-2975-647X]
dc.contributor.orcidEvans, Alex [0000-0002-8549-0146]
dc.contributor.orcidBowrin, Kevin [0000-0001-9165-471X]
dc.contributor.orcidWojciechowski, Piotr [0000-0001-8400-1171]
dc.contributor.orcidMargas, Wojciech [0000-0002-9936-0932]
dc.contributor.orcidHuelsebeck, Maria [0000-0002-3147-9945]
dc.identifier.eissn1755-5922


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