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dc.contributor.authorWatson, Christine J
dc.date.accessioned2022-06-14T01:03:13Z
dc.date.available2022-06-14T01:03:13Z
dc.date.issued2022-05-13
dc.identifier.issn0264-6021
dc.identifier.other35551601
dc.identifier.otherPMC9162463
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338061
dc.description.abstractThe mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of lactation. The milk-producing cells arise primarily during pregnancy and comprise the alveolar lineage that is specified by signalling pathways and factors that are activated in response to pregnancy hormones. There are at least two alveolar sub-lineages, one of which is marked by the presence of binucleate cells that are especially susceptible to programmed cell death during involution. This process of post-lactational regression, or involution, is carefully orchestrated and occurs in two phases, the first results in a rapid switch in cell fate with the secretory epithelial cells becoming phagocytes whereupon they destroy dead and dying cells from milk. This reversible phase is followed by the second phase that is marked by an influx of immune cells and a remodelling of the gland to replace the alveolar cells with re-differentiated adipocytes, resulting in a return to the pre-pregnant state in preparation for any subsequent pregnancies. The mouse mammary gland provides an excellent experimental tool with which to investigate lineage commitment and the mechanisms of programmed cell death that occur in a normal physiological process. Importantly, involution has highlighted a role for lysoptosis, a mechanism of cell death that is mediated by lysosomal cathepsins and their endogenous inhibitors, serpins. In this review, I discuss alveolar lineage commitment during pregnancy and the programmed cell death pathways that destroy these cells during involution.
dc.languageeng
dc.publisherPortland Press Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 2984726R
dc.sourceessn: 1470-8728
dc.subjectMammary gland
dc.subjectStat3
dc.subjectCell death
dc.subjectLineage
dc.subjectCathepsins
dc.subjectBinucleate
dc.subjectMammary Glands, Animal
dc.subjectEpithelial Cells
dc.subjectAnimals
dc.subjectMice
dc.subjectCell Death
dc.subjectApoptosis
dc.subjectLactation
dc.subjectPregnancy
dc.subjectFemale
dc.subjectAlveolar Epithelial Cells
dc.titleAlveolar cells in the mammary gland: lineage commitment and cell death.
dc.typeArticle
dc.date.updated2022-06-14T01:03:13Z
prism.endingPage1006
prism.issueIdentifier9
prism.publicationNameBiochem J
prism.startingPage995
prism.volume479
dc.identifier.doi10.17863/CAM.85470
dcterms.dateAccepted2022-04-21
rioxxterms.versionofrecord10.1042/BCJ20210734
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidWatson, Christine J [0000-0002-8548-5902]
dc.identifier.eissn1470-8728
cam.issuedOnline2022-05-12


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International