This is not the latest version of this item. The latest version can be found here.
Reciprocal Best Structure Hits
Repository URI
Repository DOI
No Thumbnail Available
Type
Dataset
Change log
Authors
Monzon, Vivian
Paysan-Lafosse, Typhaine
Bateman, Alex
Description
In this work, we are using AlphaFold structure models to find the closest homologues proteins between Homo sapiens and D. melanogaster, C. elegans, S. cerevisiae and S. pombe as well as between S. cerevisiae and S. pombe. We are using the structure aligner Foldseek to run all against all and search for the best scoring hit in both directions to detect the Reciprocal Best Structure Hits (RBSH). We compare the results to protein pairs detected by their sequence similarity as Reciprocal Best Hits (RBH) and verify the results using the PANTHER family classification files.
Note: This dataset is an earlier version of a more up-to-date dataset at https://doi.org/10.17863/CAM.87873
Version
Software / Usage instructions
We used the structure aligner Foldseek to find the RBSH as well as the sequence aligner BLASTP to find the RBH.
Keywords
AlphaFold database, Protein homology, Schizosaccharomyces pombe, Structure comparison
