Reciprocal Best Structure Hits
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Monzon, V., Paysan-Lafosse, T., Wood, V., & Bateman, A. (2022). Reciprocal Best Structure Hits [Dataset]. https://doi.org/10.17863/CAM.85487
In this work, we are using AlphaFold structure models to find the closest homologues proteins between Homo sapiens and D. melanogaster, C. elegans, S. cerevisiae and S. pombe as well as between S. cerevisiae and S. pombe. We are using the strcuture aligner Foldseek to run all against all and search for the best scoring hit in both directions to detect the Reciprocal Best Structure Hits (RBSH). We compare the results to protein pairs detected by their sequence similarity as Reciprocal Best Hits (RBH) and verify the results using the PANTHER family classification files.
We used the structure aligner Foldseek to find the RBSH as well as the sequence aligner BLASTP to find the RBH.
Protein homology, AlphaFold database, Structure comparison, Schizosaccharomyces pombe
This record's DOI: https://doi.org/10.17863/CAM.85487
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/