Learning from maternal deaths due to uterine rupture: review of cases from peri-urban Uganda
CHUKWUMA, Sarah M
AJOG Global Reports
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NAMAGEMBE, I., CHUKWUMA, S. M., NAKIMULI, A., KIWANUKA, N., BYAMUGISHA, J., Moffett, A., & Aiken, C. Learning from maternal deaths due to uterine rupture: review of cases from peri-urban Uganda. AJOG Global Reports https://doi.org/10.17863/CAM.85509
Background: Maternal deaths from uterine rupture continue to occur globally, with particularly high rates in Sub-Saharan Africa. Maternal death reviews have been shown to be an effective part of cohesive strategies to prevent future deaths. Objectives: To conduct maternal death reviews for all deaths following uterine rupture in the study center. To assess preventability and to synthesise key learning points that may help to prevent future maternal deaths following uterine rupture. Study design: Thorough case reviews of all maternal deaths during 2016-2018 at the study center (a national referral hospital in urban Uganda) were conducted by trained multidisciplinary panels of obstetricians and midwives. Medical records of women who died following uterine rupture (n=37, 10.6% of all maternal deaths) were extracted for further analysis. Results: The majority of maternal deaths due to uterine rupture (36/37, 97%) were preventable, with most still potentially preventable after women had reached the study center (24/36, 67%). Obstructed labor was the leading cause of uterine rupture, accounting for 73% (27/37 cases). Previous Cesarean section was confirmed in 38% (14/37 cases). The incidence of grand multiparity was 11% (4/37) and 11% (4/37) were primiparous. The majority of women (28/37; 76%) died within 24 hours of admission. On arrival at the study center, 19 (51%) were critically ill. Exploratory laparotomy was performed in 54% (20/37 cases), and a further 35% (13/37) died while awaiting laparotomy. Four women died shortly after arrival at the study center (within 1 hour) and received basic resuscitative treatment. 27% (10/37) of women who died had received antenatal planning or preparation. Conclusions: The majority deaths due to uterine rupture were preventable. The key lessons that emerged from the reviews were: (i) careful birth preparation and complication awareness for women with known risk factors, (ii) early recognition of obstructed labor, (iii) close monitoring of obstetric interventions known to be associated with uterine rupture and (iv) treating incipient or suspected uterine rupture as a time-critical obstetric emergency. The recommendations emerging from our narrative reviews are suitable for implementation in low resource obstetric settings, where high numbers of deaths involving uterine rupture occur.
This work was supported through the DELTAS Africa programme grant # DEL15-011. The DELTAS Africa programme is an independent funding scheme of The African Academy of Sciences (The AAS) supported by Wellcome 07742/Z/15/Z and the UK government. At The AAS, DELTAS Africa is implemented through AESA (Accelerating Excellence in Science in Africa), the Academy’s agenda and programmatic platform, created in collaboration with the African Union (AUDA-NEPAD) Agency.
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This record's DOI: https://doi.org/10.17863/CAM.85509
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338100
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