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dc.contributor.authorMetcalf, C Jessica E
dc.contributor.authorPaireau, Juliette
dc.contributor.authorO'Driscoll, Megan
dc.contributor.authorPivette, Mathilde
dc.contributor.authorHubert, Bruno
dc.contributor.authorPontais, Isabelle
dc.contributor.authorNickbakhsh, Sema
dc.contributor.authorCummings, Derek AT
dc.contributor.authorCauchemez, Simon
dc.contributor.authorSalje, Henrik
dc.date.accessioned2022-06-15T09:00:16Z
dc.date.available2022-06-15T09:00:16Z
dc.date.issued2022-06
dc.date.submitted2021-10-13
dc.identifier.issn2054-5703
dc.identifier.otherrsos211498
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338108
dc.description.abstractComparing age and sex differences in SARS-CoV-2 hospitalization and mortality with MERS-CoV, seasonal coronaviruses, influenza and other health outcomes opens the way to generating hypotheses as to underlying mechanisms driving disease risk. Using 60-year-olds as a reference age group, we find that relative rates of hospitalization and mortality associated with the emergent coronaviruses are lower during childhood and start to increase earlier (around puberty) as compared with influenza and seasonal coronaviruses. The changing distribution of disease risk by age for emerging pathogens appears to broadly track the gradual deterioration of the immune system (immunosenescence), which starts around puberty. By contrast, differences in severe disease risk by age from endemic pathogens are more decoupled from the immune ageing process. Intriguingly, age-specific sex differences in hospitalizations are largely similar across endemic and emerging infections. We discuss potential mechanisms that may be associated with these patterns.
dc.languageen
dc.publisherThe Royal Society
dc.subjectScience, society and policy
dc.subjectResearch articles
dc.subjectcomparing
dc.subjectage
dc.subjectsex
dc.subjecttrajectories
dc.subjectSARS
dc.subjectCoV-2
dc.titleComparing the age and sex trajectories of SARS-CoV-2 morbidity and mortality with other respiratory pathogens.
dc.typeArticle
dc.date.updated2022-06-15T09:00:16Z
prism.issueIdentifier6
prism.publicationNameR Soc Open Sci
prism.volume9
dc.identifier.doi10.17863/CAM.85517
dcterms.dateAccepted2022-05-27
rioxxterms.versionofrecord10.1098/rsos.211498
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMetcalf, C Jessica E [0000-0003-3166-7521]
dc.contributor.orcidHubert, Bruno [0000-0003-3640-718X]
dc.contributor.orcidSalje, Henrik [0000-0003-3626-4254]
dc.identifier.eissn2054-5703
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) ERC (804744)
cam.issuedOnline2022-06-15


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